Modified human insulin and its use as starting material for the

Details Modified human insulin and its use as starting material for the Modified human insulin and its use as starting material for the

1985-08-20

1989-06-20

Huleatt, Jayme A.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

435 70, 435 71, 530303, C12P 2106, C12P 2102, C12P 2104, C07K 740

Patent

active

048408972

ABSTRACT:
A novel modified human insulin of the general formula: ##STR1## wherein R is a hydrophobic or charged amino acid or a di- or tripeptide group, comprising a hydrophobic or charged amino acid or an amide or ester of said amino acid or peptide and its use as starting material for the preparation of human insulin.

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patent: 4182654 (1980-01-01), Royer
patent: 4320196 (1982-03-01), Morihara et al.
patent: 4320197 (1982-03-01), Morihara et al.
patent: 4343898 (1982-08-01), Markussen
patent: 4639332 (1987-01-01), Grau
patent: 4645740 (1987-02-01), Breddam et al.
Breddam, K. et al, Carlsberg Research Communications, vol. 46, pp. 361-372, 1981.
K. Morihara et al, "Semi-Synthesis of Human Insulin by Trypsin Catalysed Replacement of Ala-B30 by Thr in Porcine Insulin", Nature, vol. 280, No. 5721, Aug. 1979, pp. 412-413.
K. Morihara et al, "Synthesis of Human Insulin. Semi-Synthesis from Swine Insulin with High Yield", Chemical Abstracts: vol. 95, No. 5, 1982, p. 331.
K. Morihara et al, "Achromobacter Protease I-Catalyzed Conversion of Porcine Insulin into Human Insulin", Biochem and Biophys Research Communications, vol. 92, pp. 396-402, 1980.

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