Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Hormones – e.g. – prolactin – thymosin – growth factors – etc.
Patent
1993-12-21
1996-11-05
Hendricks, Keith D.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Hormones, e.g., prolactin, thymosin, growth factors, etc.
530350, C07K 14475
Patent
active
055718957
ABSTRACT:
The present invention relates to a glia activating factor (GAF) in which 33 to 49 N-terminal amino acids are deleted from the N-terminus of the GAF polypeptide of SEQ ID NO: 3, as well as an anti-GAF antibody which is highly sensitive to assay the GAF and is capable of neutralizing GAF's activity, is produced.
Using the antibody, GAF and its biological activity can be assayed easily with high sensitivity. Further, the neutralizing antibody can be expected to have preventive and curative effects on diseases caused by GAF's excessive action. Furthermore, the GAF polypeptide disclosed herein is more stable to acids and heat than the conventional GAFs, therefore, it can be used as a platelet-increasing agent, etc., more advantageously than the previously known GAFs.
REFERENCES:
Ken-ichi Naruo et al.; J. Biol. Chem., 268, 2857 (1993).
Masaaki Miyamoto et al., Mol. Cell Biol., 13, 4251 (1993).
Kurokawa Tsutomu
Kuroshima Ken-ichi
Seko Chisako
Yoshitomi Sumie
Conlin David G.
Hendricks Keith D.
Resnick David S.
Takeda Chemical Industries Ltd.
LandOfFree
Modified GAF polypeptides does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Modified GAF polypeptides, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Modified GAF polypeptides will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2015871