Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1992-04-22
1993-12-07
Ivy, C. Warren
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
540456, A61K 3133, C07D49816
Patent
active
052683702
ABSTRACT:
Described is a new immunosuppressant, L-683,519, a monodemethylated rearranged derivative of L-679,934, (FK-506) produced under fermentation conditions utilizing the microorganism, unidentified Actinomycete (Merck Culture Collection MA 6474) ATCC No. 53828. The macrolide immunosuppressant is useful in preventing human host rejection of foreign organ transplants, e.g. bone marrow and heart transplants.
REFERENCES:
patent: 4894366 (1990-01-01), Fujisawa
patent: 4920218 (1990-04-01), Askin
patent: 4975372 (1990-12-01), Arison
patent: 5138052 (1992-08-01), Chen
JACS 1987, vol. 109, pp. 5031-5033, by Tanaka, et al., Structure of DK506: A Novel Immunosuppressant Isolated from Streptomyces.
Arison Byron H.
Chen Shieh-Shung T.
Inamine Edward S.
Wicker Linda S.
Caruso Charles M.
Chang Celia
Ivy C. Warren
Merck & Co. , Inc.
North Robert J.
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