Modified ciliary neurotrophic factor (CNTF)

Details Modified ciliary neurotrophic factor (CNTF) Modified ciliary neurotrophic factor (CNTF)

2006-10-10

2006-10-10

Hayes, Robert C. (Department: 1649)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C530S399000

Reexamination Certificate

active

07119066

ABSTRACT:
Modified ciliary neurotrophic factor, methods for production and methods of use, especially in the treatment of Huntington's disease, obesity, and gestational or adult onset diabetes.

REFERENCES:
patent: 5846935 (1998-12-01), Panayotatos
patent: 0446931 (1991-09-01), None
patent: WO/98221128 (1998-05-01), None
Rudinger, In “Peptide Hormones” (ed. J.A. Parsons), University Park Press, Baltimore, pp. 1-7 (1976).
Gloaguen, I., et al PNAS. 94:6456-6461 (1997).
Masiakowski, P et al. J Neuro57(3): 1003-1012 (1991).
Panaytatos, N. et al. J Biol. Chem 268(25): 19000-19003 (1993).
Panaytatos, N. et al.Biochem 33(19):5813-5818 (1994).
A double-blind placebo controlled clinical trial of subcutaneous recombinant ciliary neurotrophic factor (rCNTF) in amyotrophic lateral sclerosis. Neurology 46:1244-1249 (1996).

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