Modified cholera toxin based on mutagenized subunit A

Details Modified cholera toxin based on mutagenized subunit A Modified cholera toxin based on mutagenized subunit A

1995-05-24

1998-06-23

Prouty, Rebecca E.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Amino acid sequence disclosed in whole or in part; or...

4241851, 4242611, 424945, 424832, 530350, 435193, A61K 39106, C12N 910, C07K 1428

Patent

active

057702039

ABSTRACT:
The development of subunits and subunit analogs of the cholera exotoxin by recombinant DNA techniques provides vaccine products that can retain their biological activity and immunogenicity, and can confer protection against disease challenge. Genetically-engineered modifications of the subunits result in products that retain immunogenicity, yet are reduced in, or are essentially free of, enzymatic activity associated with toxin reactogenicity.

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