Modified Bordetella adenylate cyclase comprising or...

Details Modified Bordetella adenylate cyclase comprising or... Modified Bordetella adenylate cyclase comprising or...

2011-03-15

2011-03-15

Swartz, Rodney P. (Department: 1645)

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

C424S009100, C424S009200, C424S184100, C424S190100, C424S278100, C530S300000, C530S350000

Reexamination Certificate

active

07906123

ABSTRACT:
The invention relates to modifiedBordetellaadenylate cyclase toxins which are deficient for CD11b/CD18 binding and to their use in the preparation of pharmaceutical composition for the treatment of whooping cough and/or for the protection againstBordetellainfection. The invention also relates to specific fragments ofBordetellaadenylate cyclase comprising the CD11b/CD18 interaction domain and their use, especially for targeting a molecule of interest to CD11b expressing cells.

REFERENCES:
patent: 6309648 (2001-10-01), Betsou et al.
patent: 2006/0159697 (2006-07-01), Leclerc et al.
patent: 0 366 549 (1990-05-01), None
patent: 1 188 446 (2002-03-01), None
patent: WO 91 08294 (1991-06-01), None
patent: WO 93 21324 (1993-10-01), None
Westrop et al. Journal of Bacteriology, vol. 179, No. 3,. pp. 871-879, Feb. 1997).
Osicka et al. Infection and Immunity, vol. 68, No. 1, pp. 247-256, Jan. 2000).
International Search Report in corresponding PCT application PCT/EP2004/007811.
European Search Report in corresponding EP application EP 03 29 1486.
Osicka et al., Delivery of CD8+ T-Cell Epitopes Into Major Histocompatibitity Complex Class I Antigen Presentation Pathway byBordetella pertussisAdenylate Cyclase: Delineation of Cell Invasive Structures and Permissive Insertion Sites,Infection and Immunity, vol. 68:1, Jan. 2000, pp. 247-256.
Westrop et al, Structure-Function Studies of the Adenylate Cyclase Toxin ofBordetella pertussisand the Leukotoxin ofPasteurella haemolyticaby Heterologous C Protein Activation and Construction of Hybrid Proteins,Journal of Bacteriology, vol. 179:3, Feb. 1997, pp. 871-879.
Fayolle et al., Delivery of Multiple Epitopes by Recombinant Detoxified Adenylate Cyclase ofBordetella pertussisInduces Protective Antiviral Immunity,Journal of Virology, vol. 75:16, Aug. 2001, pp. 7330-7338.
Guermonprez., In Vivo receptor-Mediated Delivery of a Recombinant Invasive Bacterial Toxoid to CD11c+CD8α·CD11bhighDendritic Cells,Eur. J. Immunol., vol. 32:11, Nov. 2002, pp. 3071-3081.
Betsou et al., Bifunctional Hemolysia-Adenylate Cyclase Percursor (Cyclolysin) (ACT) (AC-HLY),EMBL/GENBANK/DDBJ Databases, EBI Accession No. CYAA—BORBR, Database Accession No. Q57506, Created Nov. 1, 1977.
Betsou et al, Cloning and Sequence of theBordetella bronchisepticaAdenylate Cyclase—Hemolysine-Encoding gene: Comparison withBordetella pertussisGene;Gene, vol. 162:1, Aug. 30, 1995, pp. 165-166.
Sakamoto, et al.,Bordetella pertussinsAdenylate Cyclase Toxin,J. Biol. Chem., vol. 267:19, Jul. 5, 1992, pp. 13598-13602.
Guermonprez et al., The Adenylate Cyclase Toxin ofBordetella pertussisBinds to Target Cells via the XmB2Integrin (CD11b/CD/18),J. Exp. Med., vol. 193:9, May 7, 2001, pp. 1035-1044.
U.S. Appl. No. 11/304,590, filed Dec. 16, 2005, Non-final Office Action dated Sep. 5, 2006.
International Preliminary Report on Patentability in corresponding PCT application PCT/EP2004/007811.

Affiliated with

Also associated with

Rating

Modified Bordetella adenylate cyclase comprising or... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Modified Bordetella adenylate cyclase comprising or..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Modified Bordetella adenylate cyclase comprising or... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2739502