ML-236B Derivatives

Details ML-236B Derivatives ML-236B Derivatives

1982-07-07

1984-05-08

Milestone, Norma S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

560119, 424279, C07D30930

Patent

active

044476264

ABSTRACT:
A compound of formula (I): ##STR1## (called 6-methoxy-IsoML-236B lactone) and its corresponding free hydroxy-carboxylic acid and salts and esters of said acid may be prepared by the enzymatic alkoxylation of an ML-236B compound, preferably using a microorganism of the genus Syncephalastrum, Absidia or Cunninghamella, e.g. Absidia coerulea, or a cell-free enzyme-containing extract from said microorganism. If desired, the lactone or carboxylic acid may be converted by conventional salification or esterification techniques to the desired salt or ester. These compounds have the ability to inhibit the biosynthesis of cholesterol and are thus of value in the treatment of hypercholesteraemia, for which purpose they may be formulated as compositions in admixture with conventional pharmaceutical carriers or diluents.

REFERENCES:
patent: 3983140 (1976-09-01), Endo et al.
patent: 4346227 (1982-08-01), Terahara et al.

Affiliated with

Also associated with

Rating

ML-236B Derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with ML-236B Derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and ML-236B Derivatives will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1603842