Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2005-03-08
2005-03-08
Priebe, Scott D. (Department: 1635)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C536S023100, C435S320100, C435S325000, C435S468000, C435S471000, C435S252300, C435S243000, C435S254110, C435S348000, C435S349000, C435S358000, C435S410000, C435S455000
Reexamination Certificate
active
06864364
ABSTRACT:
The present invention is directed to genes and gene products related to Min-K which form ion channels and to a process for diagnosis of ion channel disorders, including long QT syndrome (LQT). For example, KCNE2 forms IKrpotassium channels and is associated with LQT. LQT is diagnosed in accordance with the present invention by analyzing the DNA sequence of KCNE2 of an individual to be tested and comparing the respective DNA sequence to the known DNA sequence of a normal KCNE2 gene. Alternatively, these MinK-related genes of an individual to be tested can be screened for mutations which cause ion channel disorders, including LQT. Prediction of ion channel disorders, including LQT, will enable practitioners to prevent the disorders using existing medical therapy. This invention is further directed to the discovery that the HERG and KCNE2 (also known as MiRP1) proteins coassemble to form a cardiac IKrpotassium channel.
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Abbott Geoffrey W.
Goldstein Steve A. N.
Keating Mark T.
Sesti Federico
Splawski Igor
Priebe Scott D.
Rothwell Figg Ernst & Manbeck
University of Utah Research Foundation
Whiteman Brian
Yale University
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