Midecamycin biosynthetic genes

Chemistry: molecular biology and microbiology – Micro-organism – per se ; compositions thereof; proces of... – Bacteria or actinomycetales; media therefor

Reexamination Certificate

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C435S252330, C435S252310, C435S252350, C435S320100, C536S023200, C536S023700, C536S023100

Reexamination Certificate

active

07070980

ABSTRACT:
The present invention provides an isolated polypeptide comprising a nucleotide sequence encoding a protein which is involved in midecamycin biosynthesis, wherein the protein contains an amino acid sequence selected from SEQ ID NOs: 2 to 10, 13, 14, 16, 19, 20, 22 to 26, and 28 to 38 or a modified amino acid sequence of the amino acid sequence having one or more amino acid modifications without affecting activity of the protein.

REFERENCES:
patent: 5876991 (1999-03-01), DeHoff et al.
Hara et al. Cloning of midecamycin(MLS)-resistance genes fromStreptomyces mycarofaciens, Streptomyces lividansandStreptomyces coelicolorA3(2). J Antibiot (Tokyo). 43(8):977-991, Aug. 1990.
Scott et al. The Pendred syndrome gene encodes a chloride-iodide transport protein. Nat Genet. 21(4):440-3, Apr. 1999.
Everett et al. Pendred syndrome is caused by mutations in a putative sulphate transporter gene (PDS). Nat Genet. 17(4):411-22, Dec. 1997.
Fetrow. Functional analysis of theEscherichia coligenome using the sequence-to-structure-to-function paradigm: identification of proteins exhibiting the glutaredoxin/thioredoxin disulfide oxidoreductase activity. J Mol Biol. 282(4):703-11, Oct. 1998.
Kakavas et al. Identification and characterization of the niddamycin polyketide synthase genes fromStreptomyces caelestis. Journal of Bacteriology. 179(23):7515-7522, Dec. 1997.
Yiguang et al. Cloning of midecamycin biosynthetic genes fromStreptomyces mycarofaciens1748. 5(4):191-201, 1989.
Pakula. Genetic analysis of protein stability and funciton. Annu Rev Genet. vol. 23, pp. 289-310, 1989.
Neil Bate, et al., The mycinose-biosynthetic genes ofStreptomyces fradie, product of tylosin, Journal of Industrial Microbiology & Biotechnology, vol. 23, (1999), pp. 118-122.
Neil Bate, et al., Multiple regulatory genes in the tylosin biosynthetic cluster ofStreptomyces fradiae, Chemistry & Biology, vol. 6, No. 9, (1999), pp. 617-624.
Neil Bate, et al., The mycarose-biosynthetic genes foStreptomyces fradiae, producer of tylosin, Microbiology, vol. 146, (2000), pp. 139-146.
V.A. Birmingham, et al., Mol. Gen. Genet, Cloning and expression of a tylosin resistance gene from a tylosin-producing strain ofStreptomyces fradiae, vol. 204, (1986), pp. 532-539.
Eric Cundliffe, et al., The tylosin-biosynthetic genes ofStreptomyces fradiae, Antonie Van Leeuwenhoek, vol. 79, (2001), pp. 229-234.
S.E. Fishman, et al., Cloning genes for the biosynthesis of a macrolide antibiotic, Proc. Natl. Acad. Sci. USA, vol. 84, (Dec. 1987), pp. 8248-8252.
Roberto Fouces, et al., The tylosin biosynthetic cluster fromStreptomyces fradiae: genetic organizationof the left region, Microbiology, vol., 145, (1999), pp. 855-868.
Atul R. Gandecha, et al., Molecular analysis of trlrD, an MLS resistance determinant from the tylosin producer,Streptomyces fradiae, GENE, vol. 180, (1996), pp. 173-176.
Atul R. Gandecha, et al., Analysis of four tylosin biosynthetic genes from the tyILM region of theStreptomyces fradiaegenome, GENE, vol. 184, (1997), pp. 197-203.
Osamu Hara, et al., A Macrolide 3-O-Acyltransferase Gene from the Midecamycin-Producing SpeciesStreptomyces mycarofaciens, Journal of Bacteriology, vol., 174, No. 15, (1992), pp. 5141-5144.
Louise A. Merson-Davies, et al., Analysis of five tylosin biosynthetic genes from the tyIIBA region of theStreptomyces fradiaegenome, Molecular Microbiology, vol. 13, No. 2, (1994), pp. 349-355.
Paul R. Rosteck, et al., Homology between proteins controllingstreptomyces fradiaetylosin resistance and ATP-binding transport, GENE, vol. 102, (1991), pp. 27-32.
Vanessa T.W. Wilson, et al., Characterization and targeted disruption of a glycosyltransferase gene in the tylosin producer,Streptomyces fradiae, GENE, vol. 214, (1998), pp. 95-100.
Kai Wu, et al., The FK520 gene cluster ofStreptomyces hygroscopicus var. ascomyceticus(ATCC 14891) contains genes for biosynthesis of unusual polyketide extender units, GENE, vol. 251, (2000), pp. 81-90.
Li Jun, et al., Phylogeny of Extra-Slowly-Growing Rhizobia Isolated from the Nodules of Soybean, Acta Microbiologica Sinica, vol. 36, (1996), pp. 416-422.

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