Chemistry: molecular biology and microbiology – Apparatus – Including measuring or testing
Patent
1995-09-15
2000-05-02
Sisson, Bradley L.
Chemistry: molecular biology and microbiology
Apparatus
Including measuring or testing
435 6, 435 911, 436 94, 422 50, 422109, 422110, C12M 100, C12Q 168, G01N 3300, G05D 2300
Patent
active
060571497
ABSTRACT:
The movement and mixing of microdroplets through microchannels is described employing silicon-based microscale devices, comprising microdroplet transport channels, reaction regions, electrophoresis modules, and radiation detectors. The discrete droplets are differentially heated and propelled through etched channels. Electronic components are fabricated on the same substrate material, allowing sensors and controlling circuitry to be incorporated in the same device.
REFERENCES:
patent: 4683195 (1987-07-01), Mullis et al.
patent: 4683202 (1987-07-01), Mullis et al.
patent: 5091328 (1992-02-01), Miller
patent: 5160945 (1992-11-01), Drake
patent: 5498392 (1996-03-01), Wilding et al.
patent: 5533412 (1996-07-01), Jerman et al.
patent: 5585069 (1996-12-01), Zanzucchi et al.
patent: 5587128 (1996-12-01), Wilding et al.
patent: 5651839 (1997-07-01), Rauf
patent: 5700637 (1997-12-01), Southern
Marmur and Lane, Proc.Nat.Acad.Sci., U.S.A. 46, 453 (1960).
Doty et al. Proc.Nat.Acad.Sci., U.S.A. 46, 461 (1960).
Hayashi et al., Proc.Nat.Acad.Sci., U.S.A. 50, 664 (1963).
Smith and Wilcox, J.Mol.Biol. 51, 379 (1970).
Southern, J.Mol.Biol. 98, 503 (1975).
Maxam and Gilbert, Proc. Natl. Acad. Sci. USA 74:560 (1977).
Sanger et al., Proc. Natl. Acad. Sci. USA 74:5463 (1977).
Graham et al., "Direct DNA sequencing using avian myeloblastosis virus and Moleney murine leukemia virus reverse transcriptase" Bethesda Res. Lab. Focus 8(2): (1986).
Sambrook, J. et al. Molecular Cloning, A Laboratory Manuel, 2d Ed. Cold Spring Harbor Laboratory Press, New York, 13.7-13.9.
Hunkapiller, M.W. Curr. Op. Gen. Devl. 1:88-92 (1991).
Tabor et al., Proc. Natl. Acad. Sci. USA 84:4767 (1987).
Innis et al., Proc. Natl. Acad. Sci. USA 85:9436 (1988).
J. Pfahler et al., Sensor and Actuators, A21-A23, pp. 431-434 (1990).
H.T.G. Van Lintel et al., Sensors and Actuators 15:153-167 (1988).
Smits, "Piezoelctric Micropump with Three Valves Working Peristaltically," Sensors and Actuators A21-A23:203 (1990).
Mullis and Faloona, "Specific Synthesis of DNA in Vitro via a Polymerase-Catalyzed Chain Reaction," Meth. Enzym. 155:335 (1987).
Arnheim, "Polymerase Chain Reacton Strategy," Annu. Rev. Biochem. 61:131 (1992).
Nickerson et al., "Automated DNA diagnostics using a ELISA-based oligonucleotide ligation assay," Proc. Nat. Acad. Sci. USA 87:8923 (1990).
Gordon et al., "Capillary Electrophoresis," Science 27:224 (1988).
Lawrence Berkeley Lab Presentation, Park City, Utah (1993).
Turner, "New Dimensions in Capillary Electrophoresis Columns," LC-GC vol. 9 (1991).
Heller and Tullis, "Microelectrophoresis for the separation of DNA fragments," Electrophoresis 13:512 (1992).
Manz et al., "Planar chips technology for miniaturization and integration of separation techniques into monitoring systems Capillary electrophoresis on a chip," J. Chrom. 593:253 (1992).
Jorgenson and Lukacs, "High-Resolution Separations Based on Electrophoresis and Electroosmosis," J. Chrom. 218:209 (1981).
Chamberlain et al., "BRCA1 Maps Proximal to D17S579 on Chromosome 17q21 by Genetic Analysis", Am. J. Hum. Genet. 52:792 (1993).
Ansorge et al., "High-throughput automated DNA sequencing facility with fluorescent labels at the European Molecular Biology Laboratory," Electrphoresis 13:616 (1992).
Pentoney et al., "A single-fluor approach to DNA sequence determination using high performance capillary electrophoresis," Electrophoresis 13:467 1992).
Daniel et al., French patent #2,672,301.
Tenan et al., "Friction in Capillary Systems," Journal of Applied Physics 53:6687 (1982).
Dussan, "On the Spreading of Liquids on Solid Surfaces Static and Dynamic Contact Lines," Annual Review of Fluid Mechanics 11:371 (1979).
Probstein, "Physicochemical Hydrodynamics," (1989).
R.F. Service, "The Incredible Shrinking Laboratory," Science 268:26 (1995).
Presentation at Cold Spring Harbor (Aug. 31-Sep. 2, 1995).
R. Nowak, "Xeroxing DNA Analysis".
Burke David T.
Burns Mark A.
Fields Yakeitha
Foerster Bradley
Johnson Brian N.
Sisson Bradley L.
The University of Michigan
LandOfFree
Microscale devices and reactions in microscale devices does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Microscale devices and reactions in microscale devices, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Microscale devices and reactions in microscale devices will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1592958