Microprecipitation method for preparing submicron suspensions

Details Microprecipitation method for preparing submicron suspensions Microprecipitation method for preparing submicron suspensions

2006-05-02

2006-05-02

Page, Thurman K. (Department: 1618)

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

C424S400000, C424S450000, C264S004000, C264S004100, C264S005000

Reexamination Certificate

active

07037528

ABSTRACT:
The present invention provides a method for preparing submicron sized particles of an organic compound, the solubility of which is greater in a water-miscible first solvent than in a second solvent which is aqueous, the process including the steps of: (i) dissolving the organic compound in the water-miscible first solvent to form a solution, (ii) mixing the solution with the second solvent to define a pre-suspension; and (iii) adding energy to the pre-suspension to form particles having an average effective particle size of 400 nm to 2 microns.

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