Microbial process for preparing mevinolin by a strain of aspergi

Details Microbial process for preparing mevinolin by a strain of aspergi Microbial process for preparing mevinolin by a strain of aspergi

1993-06-17

1995-04-04

Knode, Marian

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing heterocyclic carbon compound having only o, n, s,...

435123, 435127, 435132, 435171, 4352561, C12P 1706, C12P 700, C12P 702

Patent

active

054037280

ABSTRACT:
The invention refers to a new microbial process for preparing .beta.,.delta.-dihydroxy-7-[1,2,6,7,8,8a-hexahydro-2.6-dimethyl-8-(2-methy l-butyryloxy)-naphthalen-1-yl]-heptanoic acid .delta.-lactone of formula (I) and .beta.,.delta.-dihydroxy-7-[1,2,6,7,8,8a-hexahydro-2.6-dimethyl-8-(2-methy lbutyryloxy)-naphtalen-1-yl]-heptanoic acid of formula (II), ##STR1## by the aerobic fermentation of the submerged culture of an imperfect fungus strain biosynthesizing the above compounds, in a nutrient medium containing utilizable carbon and nitrogen sources as well as mineral salts, and by isolating the product of formula (I), which comprises cultivating a strain of the new Aspergillus obscurus fungus species producing the above compound(s) of formulas (I) and/or (II), in a temperature range of 25.degree. to 30.degree. C. and, if desired, separating the product(s) formed from the fermentation broth, then isolating it in the lactone form of formula (I) and, if desired, purifying the same.

REFERENCES:
patent: 4231938 (1980-11-01), Monaghan
patent: 4319039 (1982-03-01), Albers=Schmberg
patent: 5153124 (1992-10-01), Furuya

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