MHCD and microfluidic apparatus and method

Details MHCD and microfluidic apparatus and method MHCD and microfluidic apparatus and method

2001-08-20

2003-07-01

Han, Jessica (Department: 2838)

Electric lamp and discharge devices: systems

Discharge device load with fluent material supply to the...

Plasma generating

C315S111410, C250S307000, C257S021000, C216S041000

Reexamination Certificate

active

06586885

ABSTRACT:

FIELD OF THE INVENTION
This invention relates to microhollow cathode discharge devices and to microfluidic devices and more particularly to structures and methods of integrating the devices.
BACKGROUND OF THE INVENTION
In gas and liquid sample analysis, capillary electrophoresis, blood chemistry analysis and analytical chemistry, smaller dimensions of capillaries often provide improved performances in throughput, speed, and reduced production or analysis costs (e.g. less reagents, smaller sample size, etc.). More recently, miniaturized planar separation systems (e.g. total microanalysis systems or lab-on-a-chip) have been fabricated by micromachining or microlithographic techniques in silicon, glass, and plastics. See for example Harrison D. J. et al.,
Science,
1993, 261, 895.
Although many separation systems have been demonstrated on-chip, there are only a few approaches to having on-chip optical detection systems reported into the literature. To date, epifluorescence detection external to a chip is commonly used for large channels of a few hundreds of microns in cross-section but there are needs for more sensitive optical detectors capable of measuring the passage of a small number of molecules in narrower channels. There are advantages to develop techniques to form channels with dimensions possibly smaller than the persistence length of a DNA polymer in order to extend the molecular strand to map its sequence. Single molecule manipulation will require high spatial resolution near-field optical probes requiring to go to some form of non-propagating evanescent mode. See for example, U.S. Pat. No. 5,623,339, entitled “Interferometric Measuring Method Based on Multiple Sensing” and U.S. Pat. No. 5,623,338, entitled “Interferometric Near-Field Apparatus Based on Multiple Sensing”, incorporated herein by reference. Although narrow apertures can be easily formed in various evaporated metallic films on a transparent substrate combined with a microchannel, it is very challenging to place a light source directly on-chip.
Accordingly it is highly desirable to provide new and improved integrated microhollow cathode discharge, for example as a light source, and microfluidic devices and methods of fabrication


REFERENCES:
patent: 4274063 (1981-06-01), Javan
patent: 5623338 (1997-04-01), Wickramasinghe et al.
patent: 5817242 (1998-10-01), Biebuyck et al.
patent: 6136212 (2000-10-01), Mastrangelo et al.
patent: 6180239 (2001-01-01), Whitesides et al.
patent: 19941270 (2001-06-01), None
patent: 0231639 (1987-08-01), None
patent: 0469733 (1992-02-01), None
Vojak et al., “Multistage, monolithic ceramic microdishcharge device having an active length of ~0.27mm” Applied Physics Letters, vol. 78, No. 10, Mar. 5, 2001, pp. 1342.

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