Methods using proton pump inhibitors and nitric oxide donors

Details Methods using proton pump inhibitors and nitric oxide donors Methods using proton pump inhibitors and nitric oxide donors

2005-02-08

2005-02-08

Rao, Deepak (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S254030, C514S361000, C514S233200, C514S300000, C514S303000, C514S260100, C544S368000, C544S134000, C544S127000, C544S324000, C544S323000, C544S284000, C546S273700, C546S121000, C546S112000, C546S115000, C546S118000, C548S126000

Reexamination Certificate

active

06852739

ABSTRACT:
The present invention describes novel nitrosated and/or nitrosylated proton pump inhibitor compounds, and novel compositions comprising at least one proton pump inhibitor compound that is optionally substituted with at least one NO and/or N02group, and, optionally, at least one compound that donates, transfers or releases nitric oxide, stimulates endogenous synthesis of nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor or is a substrate for nitric oxide synthase, and/or at least one nonsteroidal antiinflammatory drug, selective COX-2 inhibitor, antacid, bismuth-containing reagent, acid-degradable antibacterial compound, and mixtures thereof. The present invention also provides methods for treating and/or preventing gastrointestinal disorders; facilitating ulcer healing; decreasing the recurrence of ulcers; improving gastroprotective properties, anti-Helicobacter pyloriproperties or antacid properties of proton pump-inhibitors; decreasing or reducing the gastrointestinal toxicity associated with the use of nonsteroidal antiinflammatory compounds; treatingHelicobacter pyloriand viral infections. The compounds and/or compositions of the present invention can also be provided in the form of a pharmaceutical kit.

REFERENCES:
patent: 4045563 (1977-08-01), Berntsson et al.
patent: 4255431 (1981-03-01), Junggren et al.
patent: 4337257 (1982-06-01), Junggren et al.
patent: 4359465 (1982-11-01), Ruwart
patent: 4628098 (1986-12-01), Nohara et al.
patent: 4634710 (1987-01-01), Fischli et al.
patent: 4758579 (1988-07-01), Kohl et al.
patent: 4806549 (1989-02-01), Ife et al.
patent: 4806550 (1989-02-01), Ife et al.
patent: 4808596 (1989-02-01), Matsuishi et al.
patent: 4818760 (1989-04-01), Binder et al.
patent: 4839365 (1989-06-01), Hirai et al.
patent: 4845118 (1989-07-01), Lang et al.
patent: 4871734 (1989-10-01), Lang et al.
patent: 4873337 (1989-10-01), Sih et al.
patent: 4956366 (1990-09-01), Nimmesgern et al.
patent: 4981861 (1991-01-01), Fischli et al.
patent: 5045552 (1991-09-01), Souda et al.
patent: 5114955 (1992-05-01), Lang et al.
patent: 5149702 (1992-09-01), Yamada et al.
patent: 5380758 (1995-01-01), Stamler et al.
patent: 5391752 (1995-02-01), Hoerrner et al.
patent: 5403830 (1995-04-01), Place
patent: 5439917 (1995-08-01), Briving et al.
patent: 5470983 (1995-11-01), Slemon et al.
patent: 5554631 (1996-09-01), Kim et al.
patent: 5599794 (1997-02-01), Eek et al.
patent: 5629305 (1997-05-01), Eek et al.
patent: 5631293 (1997-05-01), Kleemann et al.
patent: 5641792 (1997-06-01), Kleemann et al.
patent: 5665730 (1997-09-01), Senn-Bilfinger et al.
patent: 5677302 (1997-10-01), Karimian et al.
patent: 5686458 (1997-11-01), Lee et al.
patent: 5703073 (1997-12-01), Garvey et al.
patent: 5703097 (1997-12-01), Kim et al.
patent: 5714504 (1998-02-01), Lindberg et al.
patent: 5750531 (1998-05-01), Lee et al.
patent: 5945425 (1999-08-01), Moormann et al.
patent: 5952504 (1999-09-01), Yoo et al.
patent: 5990311 (1999-11-01), Hong et al.
patent: 6323234 (2001-11-01), Garvey et al.
patent: 0033094 (1981-08-01), None
patent: 0045200 (1982-02-01), None
patent: 0221041 (1987-05-01), None
patent: 0234485 (1987-09-01), None
patent: 0246774 (1987-11-01), None
patent: 0254588 (1988-01-01), None
patent: 0259174 (1988-03-01), None
patent: 8908104 (1989-09-01), None
patent: 9212969 (1992-08-01), None
patent: 9527714 (1995-10-01), None
patent: WO 9624375 (1996-08-01), None
patent: WO 9725064 (1997-07-01), None
patent: 9732854 (1997-09-01), None
patent: 9818784 (1998-05-01), None
patent: 9843968 (1998-10-01), None
patent: 9857626 (1998-12-01), None
patent: 9944595 (1999-09-01), None
patent: 9945004 (1999-09-01), None
patent: 9854172 (1999-12-01), None
patent: WO 0072838 (2000-12-01), None
patent: WO 0200166 (2002-01-01), None
Beers et al., Crohn's Disease; Ulcerative Colitis, The Merck Manual of Diagnosis and Therapy, Seventeenth Edition, 1999.*
Sih et al,J. Med. Chem., 34:1049-1062 (1991).
Brunton, Goodman and Gilman, The Pharmacological Basis of Therapeutics, 9th Ed., pp. 907-915 (1996).
Wallace et al, Journal of Gastroenterology and Hepatology, 9:S40-S44 (1994).
Barrachina et al, European Journal of Pharmacology, 281:R3-R4 (1995).

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