Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1995-06-06
1998-12-01
Fitzgerald, David L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514 8, 514 12, 435 691, 435697, A61K 3816, A61K 3818
Patent
active
058438831
ABSTRACT:
The present invention relates to a keratiniocyte growth factor fragment, KGF.sub.des1-23, or an analog thereof that is composed of a portion of an amino acid sequence of mature, full length keratinlocyte growth factor, KGF.sub.163. The fragment exhibits at least a 2-fold increase in mitogenic activity as compared to a mature, recombinant keratinocyte growth factor, rKGF, but lacks a sequence comprising the first 23 amino acid residues, C-N-D-M-T-P-E-Q-M-A-T-N-V-N-C-S-S-P-E-R-H-T-R- (SEQ ID NO: 2) of the KGF.sub.163 N-terminus. The present invention also relates to a DNA molecule encoding KGF.sub.des1-23, an expression vector and a transformed host containing the DNA molecule, and a method of producing KGF.sub.des1-23 by culturing the transformed host. The present invention further relates to a conjugate of KGF.sub.des1-23 and a toxin molecule, and the use thereof for treatment of hyperproliferative disease of the epidermis. Moreover, the present invention relates to a therapeutic composition containing KGF.sub.des1-23 and a pharmaceutically acceptable carrier and the use thereof for wound healing purposes.
REFERENCES:
Curti. 1993. Crit. Rev. Oncology/Hematology 14:29-39.
Jain. 1994. Sci. Amer. 271:58-65.
Robinson. 1992. TibTech 10:1-2.
Meyer-Ingold. 1993. TibTech 11:387-392.
Bowie et al. 1990. Science 247:1306-1310.
Ron et al. 1993. J. Biol. Chem. 268;2984-2988.
Bellosta et al. J. Cell. Biol. 121:705-713.
Finch et al., Science 2:752-755 (1989).
Gospodarowicz Denis J.
Masiarz Frank R.
Blackburn Robert P.
Chiron Corporation
Fitzgerald David L.
Guth Joseph H.
Kemmerer Elizabeth C.
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