Methods of treatment of viral infections using carbocyclic deoxy

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

514262, 544276, 544277, A61K 3152

Patent

active

060018402

ABSTRACT:
Method for prophylaxis and treatment of a viral infection characterized by the administration of a composition comprising a substantial molar excess of the D-stereoisomer of 2'CdG over the L-stereoisomer.

REFERENCES:
patent: 4177348 (1979-12-01), Shealy et al.
patent: 4232154 (1980-11-01), Shealy et al.
patent: 4396623 (1983-08-01), Shealy et al.
patent: 4543255 (1985-09-01), Sheely et al.
patent: 4728736 (1988-03-01), Shealy et al.
patent: 4857531 (1989-08-01), Borthwick et al.
patent: 4916224 (1990-04-01), Vince et al.
patent: 4931559 (1990-06-01), Vince et al.
patent: 4950758 (1990-08-01), Vince et al.
Bennett, Jr. et al., Annals NY Acad Sci. 255:342-358, 1975, "Studies on the Biochemical Basis for the Antiviral Activities of Some Nucleoside Analogs. "
Bavand et al., Journal of Virology 63:1019-1021, 1989, "The Hepatitis B Virus-Associated Reverse Transcriptase Is Encoded by the Viral pol Gene."
Beach et al., Journal of Org. Chem. 57:2217-2219, 1992, "Syntheses of Enantiomerically Pure (2'R, 5'S)-(-)-1-[2-(Hydroxymethyl)oxathiolan-5-yl]cytosine as a Potent Antiviral Agent against Hepatitis B Virus . . . ".
Buthala, Annals NY Acad Sci. pp. 17-22, 1991, "Experience Gained in Screening for Synthetic Antiviral Compounds."
Bosch et al., in RNA Genetics vol. II, Domingo et al. (eds) CRC Press pp. 43-58, 1988, Hepatitis B Virus Replication.
Dahlberg et al., Proc. Natl. Acad. Sci. USA 84:2469-2473, 1987, "Broad Spectrum Antiretroviral Activity of of 2',3'-Dideoxynucleosides."
Furman et al., Antimicrobial Agents and Chemotherapy 36:2686-2692, 1992, "The Anti-Hepatitis B Virus Activities, Cytotoxicities, and Anabolic Profiles of the (-) and (+) Enantiomers of . . . Cystosine."
Gerin, Hematology 14:198-199, 1991, "Antiviral Agents for Hepatitis B."
Hoofnagle et al., "Antiviral Therapy of Viral Hepatitis," In Antiviral Agents and Viral Diseases of Man, Galasso et al., (eds.), Raven Press, Ltd., New York, NY, Chapter 12, pp. 415-459, 1990.
Kassianides et al., Gastroenterology 94:A552, "Effect of 2',3'-Dideoxycytidine on Duck Hepatitis B Virus", 1988.
Korba et al., Antiviral Research, 19:55-70, 1992, "Use of a standardized cell culture assay to assess activities of Nucleoside Analogs Against Hepatitis B Virus Replication."
Korba et al., Antiviral Research, 15:217-228, 1991, "A Cell Culture Assay for Compounds Which Inhibit Hepatitis B Virus Replication."
Lee et al., Antimicrobial Agents and Chemotherapy, 33:336-339, 1989, "In Vitro and In Vivo Comparison of of the Abilities of Purine and Pyrimidine 2',3'-Dideoxynucleosides To Inhibit Duck Hepadnavirus."
Nordenfelt et al., Journal of Medical Virology 22:231-236, 1987, "Inhibition of Hepatitis B Virus DNA Polymerase by 3'-Azido-3'-Deoxythymidine Triphosphate but not by Its Threo Analog."
Ponzetto et al., Hematology 14:16-24, 1991, "Adenine Arabinoside Monophosphate and Aclyclovir Monophosphate Coupled to Lactosaminated Albumin Reduce Woodchuck Hepatitis Virus Viremia at Doses Lower Than . . . ".
Price et al., Proceedings of the National Academy of Science U.S.A., 86:8541-8544, 1989, "Inhibition of Replication of Hepatitis B Virus by the Carbocyclic Analogue of 2'-Deoxyguanosine."
Price et al., Pharmacology 117:142894c, 1992, "The Mechanism of Inhibition of Hepatitis B Virus Replication by the Carbocyclic Analog of 2'-Deoxyguanosine."
Schiff, The American Journal of Gastroenterology 82:287-291, 1987, "Immunoprophylaxis of Viral Hepatitis: A Practical Guide."
Secrist et al., Journal of Medicinal Chemistry, 30:746-749, 1987, "Resolution of Racemic Carbocyclic Analogues of Purine Nucleosides through the Action of Adenosine Deaminase. Antiviral Activity of the . . . ".
Shannon, Annals NY Academy, Sci. 284:472-507, 1977, "Selective Inhibition of RNA Tumor Virus Replication In Vitro and Evaluation of Candidate Antiviral Agents In Vivo."
Shealy et al., J. Med. Chem. 30:1090-1094, 1987, "Synthesis and Antiviral Evaluation of Carbocyclic Analogues of 2-Amino-6-substituted-purine 3'-Deoxyribofuranosides."
Summers et al., Cell 29:403-415, 1982, "Replication of the Genome of a Hepatitis B-Like Virus by Reverse Transcription of an RNA Intermediate."
Suzuki et al., Biochem. Biophys. Res. Comm. 156:1144-1151, 1988, "Inhibition of Duck Hepatitis B Virus Replication by Purine 2',3'-Dideoxynucleosides."
Tabor, Viral Hepatitis and Liver Disease, A.J. Zuckerman (ed.), A.R.Lis, Inc. NY, 902-905, 1988, "Experimental Drugs for the Treatment of Viral Hepatitis: Drugs That Interfere With Viral Replication."
Thomas, Viral Hepatitis and Liver Disease, A.J. Zuckerman (ed.), A.R.Lis, Inc. NY, 817-822, 1988, Treatment of Hepatitis B Viral Infection.
Toh et al., Nature 305:827-829, 1983, "Sequence Homology Between Retroviral Reverse Transcriptase and Putative Polymerases of Hepatitis B Virus and Cauliflower Mosaic Virus."
Trepo et al., Journal of Hematology, 3:S129-S135, 1986, "Therapeutic Potential of Acyclovir and of the Interferons in HBV-Related Chronic Active Hepatitis due to HBV With or Without HDV Superinfection."
Ueda et al., Virology 169:213-216, 1989, "Short Communications--An In Vitro System for Screening Anti-Hepatitis B Virus Drugs."
Will et al., Journal of Virology 61:904-911, 1987, "Replication Strategy of Human Hepatitis B Virus."
Zuckerman, Journal of Virological Methods 17:119-126, 1987, "Screening of Antiviral Drugs for Hepadna Virus Infection in Pekin ducks: A Review."
Rosecan et al., Am. J. Opthalmol., 101:405-418, 1986, "Antiviral Therapy for Cytomegalovirus Retinitis in Aids with DihydroxyPropoxymethyl."
De Clercq et al., Antiviral Research, 3:17-24, 1983, "Broad Spectrum Antiviral Activity of the Carbocyclic Analog of 3-Deazaadenosine."
Shealy et al., Journal of Medicinal Chemistry, 27:670-674, 1984, "Synthesis & Antiviral Evaluation of Carbocyclic Analogues of Ribofuranosides of 2-Amino-6-Substituted-purines and 2-Amino-6-Substituted . . . ".
Field, (ed.) In Antiviral Agents: The Development and Assessment of Antiviral Chemotherapy, p. 10, CRC Press, Inc. Boca Raton, Florida, 1988.
Fields et al., (eds.), Virology, Raven Press, New York, pp. 498, 499, 503, 508, 580, 630, 650, 651, 1985.
Boyd et al., Antimicrobial Agents and Chemotherapy, 31:1238-1242, 1987, "Antiherpesvirus Activity of 9-(4-Hydroxy-3-Hydroxymethylbut-1-yl)Guanine (BRL 39123) in Cell Culture."
Buthala et al., Annals NY Acad Sci. 130:17-23, 1965, Experience Gained in Screening for Synthetic Antiviral Compounds.
Machida, Antimicrob. Agents and Chemotherapy, 29:524-526, 1986, "Comparison of Susceptibilities of Varicella-Zoster Virus and Herpes Simplex Viruses to Nucleoside Analogs."
DeClercq, Verh. K. Acad., Geneeskd. Belg. 50:261-290. 1988, "Towards a Selective Chemotherapy of Virus Infections. Development of Bromovinyldeoxyuridine. . . ".
Biggadike et al., J. Chem. Soc. Commun., 1083-1084, 1987, "Short Convergent Route to Homochiral Carbocyclic 2'-Deoxynucleosides and Carbocyclic Ribonucleosides."
Shealy et al., J. Pharm. Sci., 62:1432-1434, 1973, "Carbocyclic Analogs of Guanosine and 8-Azaguanosine."
Shealy et al., J of Med. Chem., 27:1416-1421, 1984, "Synthesis and Antiviral Activity of Carbocyclic Analogues of 2'-Deoxyribofuranosides of 2-Amino-6-substituted-purines and of 2-Amino-6-substituted-8-. . . ".
De Clercq et al., Antiviral Research 4:119-133, 1984, "Broad-spectrum antiviral activity of adenosine analogues."
Vince et al., Antiviral Research, 9:120, 1988, "Second International Conference on Antiviral Research, Williamsburg, VA, 1988."
Shealy et al., J of Heterocyclic Chem., 13:1015-1020, 1976, "Synthesis of the Carbocyclic Analogs of Uracil Nucleosides."
Shealy et al., J of Heterocyclic Chem., 13:1041-47, 1976, "Acid Catalyzed Cyclization of Alkoxyacryloylureas to 2.4 (1H, 3H) pyrimidinediones."
Shealy et al., J of Med. Chem., 26:155-165, 1983, "Carbocyclic Analogues of S-Substituted Uracil Nucleoside: Synthesis and Antiviral Activity."
Shealy et al., Journal of Heterocyclic Chem., 13:1353-1354, 1976, "The Carbocyclic Analog of Cytidine, Synthesis and Anti-neoplastic Activity."
Shealy et al., Journal of Heterocyclic Chem., 17:353-358, 1980, "Carbocyclic Analogs of Cytosi

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Methods of treatment of viral infections using carbocyclic deoxy does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Methods of treatment of viral infections using carbocyclic deoxy, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods of treatment of viral infections using carbocyclic deoxy will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-863678

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.