Methods of treating bacterial inflammation and granulocytopoiesi

Details Methods of treating bacterial inflammation and granulocytopoiesi Methods of treating bacterial inflammation and granulocytopoiesi

1995-05-26

1996-12-10

Draper, Garnette D.

Drug, bio-affecting and body treating compositions

Lymphokine

Interleukin

514 2, 514 8, 514 12, A61K 4505, A61K 3800, A61K 3816

Patent

active

055828230

ABSTRACT:
Disclosed are novel polypeptides possessing part or all of the primary structural conformation and one or more of the biological properties of a mammalian (e.g., human) pluripotent granulocyte colony-stimulating factor ("hpG-CSF") which are characterized in preferred forms by being the product of procaryotic or eucaryotic host expression of an exogenous DNA sequence. Sequences coding for part or all of the sequence of amino acid residues of hpG-CSF or for analogs thereof may be incorporated into autonomously replicating plasmid or viral vectors employed to transform or transfect suitable procaryotic or eucaryotic host cells such as bacteria, yeast or vertebrate cells in culture. Products of expression of the DNA sequences display, e.g., the physical and immunological properties and in vitro biological activities of isolates of hpG-CSF derived from natural sources. Disclosed also are chemically synthesized polypeptides sharing the biochemical and immunological properties of hpG-CSF.

REFERENCES:
patent: 4833127 (1989-05-01), Ono et al.
Pawinska et al. 1991. Mater. Med. Pol. 23(1):13-16, Abstract.
McWilliam et al. 1994. J. Exp. Med. 179(4):1331-1336, Abstract.
Nicola et al. 1985. Nature 314:625-628.
Welte et al. 1985. PNAS USA 82:1526-1530.
Okabe et al. 1982. J. Cell. Physiol. 110:43-49.
Tsuneoka et al. 1984. Cell. Struct. Funct. 9:67-81.
Bird, Nucleic Acids Res., 8, 1499-1504 (1980).
Clark-Lewis et al., J. Biol. Chem., 259, 7488-7494 (1984).
DeLamarter et al., EMBO J., 4, 2575-2581 (1985).
Glover, DNA Cloning, vols. 1 & 2, 191-211, 213-239 (1985).
Glover, Gene Cloning, 179-213 (1984).
Grantham et al., Nucleic Acids Res., 9, 43-74 (1981).
Gray et al., Nature, 295, 503-508 (1982).
Hunkapiller et al., Science, 219, 650-654, 659 (1983).
Lathe, J. Mol. Biol., 183, 1-12 (1985).
Marasco et al., Biochem. and Biophy. Res. Comm., 99, 1065-1072 (1981).
March et al., Nature, 315, 641-647 (1985).
Nagata et al., EMBO J., 5, 575-581 (1986).
Nagata et al., Nature, 319, 415-418 (1986).
Wang et al., Science, 228, 149-154 (1985).
Welte et al., Haematology and Blood Transfusion, 29, 398-401 (1985).
Welte et al., Lymphokine Res., 3, 4, 281 (1984).
Zsebo et al., Immunobiol., 172, 175-184 (1986).
Isuneska et al., Cell Struct. and Funct., 9, 67-81 (1984).
Suggs et al., Proc. Nat'l Acad. Sci. (USA), 78, 6613-6617 (1981).
Nomura et al., EMBO J., 5:871-876 (1986).
Kawasaki et al., Science, 230, 291-296 (1985).
Miura et al., Gene, 38, 271-274 (1985).
7th Annual Meeting of the Molecular Biology Society of Japan, Dec., 1974.
Taniguchi et al., Proc. Jpn. Acad., 55(B), 464-469 (1979).
Nagata et al., Nature, 284, 316-320 (1980).
Taniguchi et al., Nature, 302, 305-310 (1983).
Lomedico et al., Nature, 312, 458-462 (1984).
Gray et al., Nature, 312, 721-724 (1984).
Pennica et al., Nature, 312, 724-729 (1984).
Auron et al., Proc. Natl. Acad. Sci. USA, 81, 7907-7911 (1984).
Furutani et al., Nucleic Acids Res., 13, 5869-5882 (1985).
Fung et al., Nature, 307, 233-237 (1984).
Cantrell et al., Proc. Natl. Acad. Sci. USA, 82, 6250-6254 (1985).
Jacobs et al., Nature, 313, 806-810 (1985).
Cameron, J. Exp. Med., 162, 790 (1985).
Beutler, Nature, 316, 552 (1985).
Jong, J.B.C., 259, 11052 (1984).
Nikaido, Nature, 311, 631 (1984).
Baird, Biochem., 24, 7855 (1985).
Jacobs, Nature, 313, 806 (1985).
Ebina, Cell, 40, 747 (1985).
Minamino, B.B.R.C., 130, 1078 (1985).
Yoshinaka, J. Virol, 55, 870 (1985).
Lee, J.B.C., 259, 4616 (1984).
Esch, B.B.R.C., 109, 152 (1982).
Bohlen, FEBS, 185, 177 (1985).
Broze, J.B.C., 260, 10917 (1985).
Ohtsuka et al., J. Biol. Chem., 260, 2605-2608 (1985).
Ohkubo et al., Proc. Natl. Acad. Sci. USA, 80, 2196-2200 (1983).
Liang et al., Biochem. J, 229, 429-439 (1985).
Derynck et al., Cell, 287 (1984).
Ullrich et al., Nature, 309, 418 (1984).
Ullrich et al., EMBO J, 3, 361 (1984).
Ullrich et al., Nature, 313, 756 (1985).
Pennica et al., Nature, 312, 724 (1984).
Toole et al., Nature, 312, 342 (1984).
Wood et al., Nature, 312, 330 (1984).
Derynck et al., Nature, 316, 701 (1985).
Mason et al., Nature, 318, 659 (1985).
Docherty et al., Nature, 318, 66 (1985).
Lauffer et al., Nature, 318, 334 (1985).
Betscholtz et al., Nature, 320, 695 (1986).
Knopf et al., Cell, 46, 491 (1986).
Benedum et al., EMBO J., 5, 1495 (1986).
Abraham et al., Science, 233, 545 (1986).
Ullrich et al., EMBO J, 5, 2503 (1986).
Grundmann et al., Proc. Natl. Acad. Sci. USA, 83, 8024 (1986).
Bray et al., Proc. Natl. Acad. Sci. USA, 83, 8893 (1986).
Anderson et al., PNAS (USA), 80, 6836-6840 (1983).
Church et al., PNAS (USA), 81, 1991-1995 (1984).
Souza et al., American Society of Hematology, Abstract 536, p. 162a, (Nov. 1985).

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