Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1988-07-12
1991-04-16
Brown, Johnnie R.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
514 49, C07H 1909, C07H 19073
Patent
active
050083848
ABSTRACT:
In the disclosed process, an O.sup.2, 2' anhydro-1-(.beta.-D-arabinofuranosyl)thymine is formed by condensing a 2-amino-.beta.-arabinofurano[1',2':4,5,]-2-oxazoline with a compound of the formula ##STR1## wherein R.sub.1 is C.sub.1 -C.sub.4 alkyl; X is halogen or OR.sub.2, wherein R.sub.2 is H, C.sub.1 -C.sub.4 alkyl or phenyl; in the presence of a suitable solvent at about 0.degree. C. to about 150.degree. C. Catalytic agents such as dimethylaminopyridine and triethylamine may also be added to accelerate the reaction.
Protected intermediates of the anhydronucleosides and aminooxazolines are also disclosed.
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Brown Johnnie R.
Ginsburg Paul H.
Kunz Gary L.
Pfizer Inc.
Richardson Peter C.
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