Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1997-02-11
1999-12-14
Myers, Carla J.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
435 912, 536 235, 536 2431, 536 2433, C12Q 168, C07H 2104, C12P 1934
Patent
active
060015691
ABSTRACT:
A novel association between certain tumor necrosis factor microsatellite alleles and Crohn's disease has been discovered. In accordance with the present invention, there is provided methods for screening for Crohn's disease comprising detecting the presence or absence of nucleic acid of a subject encoding TNF microsatellite alleles associated with Crohn's disease, wherein the presence of nucleic acid encoding three or more of the alleles is indicative of Crohn's disease. Kits useful for screening for Crohn's disease are also provided which comprise nucleic acid encoding TNF microsatellite alleles associated with Crohn's disease.
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Plevy Scott E.
Rotter Jerome I.
Targan Stephan R.
Toyoda Hiroo
Yang Huiying
Bendrick John A.
Cedars-Sinai Medical Center
Halluin Albert P.
Myers Carla J.
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