Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2007-03-13
2007-03-13
Kaushal, Sumesh (Department: 1633)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
C435S004000, C435S069100, C536S023100, C536S023500, C536S024300, C536S024330
Reexamination Certificate
active
10336215
ABSTRACT:
The present invention provides nucleic acid and amino acid sequences of an ATP binding cassette transporter and mutated sequences thereof associated with macular degeneration. Methods of detecting agents that modify ATP-binding cassette transporter comprising combining purified ATP binding cassette transporter and at least one agent suspected of modifying the ATP binding cassette transporter an observing a change in at least one characteristic associated with ATP binding cassette transporter. Methods of detecting macular degeneration is also embodied by the present invention.
REFERENCES:
patent: 4683195 (1987-07-01), Mullis et al.
patent: 4683202 (1987-07-01), Mullis
patent: 4800159 (1989-01-01), Mullis et al.
patent: 4883750 (1989-11-01), Whiteley et al.
patent: 329 822 (1989-08-01), None
patent: 2 202 328 (1988-09-01), None
patent: WO 87/06270 (1987-11-01), None
patent: WO 88/10315 (1988-12-01), None
patent: PCT/US89/01025 (1989-05-01), None
patent: WO 89/06700 (1989-07-01), None
Dean et al Genome Res. (11(7):1156-66, 2001.
Jaakson et al, Hum Mutat. 22(5):395-403, 2003.
Allikmets et al Hum Mol Genet. 5(10):1649-55, 1996.
New England Biolabs product# 1230, Catalog 1988-1998.
Allikmets, R., et al., “A photoreceptor cell-specific ATP-binding transporter gene (ABCR) is mutated in recessive stargardt macular dystrophy,”Nature Genetics, 1997, 15, 236-246.
Allikmets, R., et al. “Mutation of the strargardt disease gene (ABCR) in age-related macular degeneration,”Science, 1997, 277, 1805-1807.
Allikmets, R., et al., “Characterization of the human ABC superfamily: isolation an mapping of 21 new genes using the expressed sequence tags database,”Hum. Mol. Genet., 1996, 5, 1649-1655.
Allikmets, R., et al., “Characterization and mapping of three new mammalian ATP-binding transporter genes from an EST database,”Mam. Genome, 1995, 6, 114-117.
Allikmets, R., et al., “Cloning and organization of the abc and mdl genes ofEscherichia coli: relationship to eukaryotic multidrug resistance,”Gene, 1993, 136, 231-236.
Altschul, S.F., et al., “Basic local alignment search tool,”J. Mol. Biol., 1990, 215, 403-410.
Anderson, K.L., “Towards the isolation of genes for recessively inherited ocular disorders: Bardet-Biedl Syndrome, Leber Congenital Amaurosis, Primary Congenital Glaucoma, and Stargardt Disease,”Ph.D. Thesis, Baylor College of Medicine, Jul. 30, 1996 (abstract).
Anderson, R.E., et al., “Lipids of ocular tissues,”Arch. Biochem. Biophys., 1971, 151, 271-276.
Azarian, S.M., et al., “The photoreceptor rim protein is an ABC transporter encoded by the gene for recessive stargardt's disease (ABCR),”FEBS Letts., 1997, 409, 247-252.
Bellanne-Chantelot, C., et al., “Mapping the whole human genome by fingerprinting yeast artificial chromosomes,”Cell, 1992, 70, 1059-1068.
Birnbach, C.D., et al., “Histopathology and immunocytochemistry of the neurosensory retina in fundus flavimaculatus,”Ophthalmology, 1994, 101, 1211-1219.
Blacharski, D.A., Fundus flavimaculatus. In retinal dystrophies and degenerations, D.A. Newsome (Ed.), 1988, New York: Raven Press, 9, 135-159.
Boguski, M.S., et al., “dbEST-database for ‘expressed sequence tags’,”Nature Genet, 1993, 4, 332-333.
Bradley, A., “Production and analysis of chimeric mice,”Teratocarcinomas and embryonic Stem Cells, A Practical Approach, 1987, Roberson (Ed.), IRL Press, 113-151.
Chen, Z.Y., et al., “Norrie disease gene: characterization of deletions and possible function,”Genomics, 1993, 16, 533-535.
Childs, S., et al., “The MDR superfamily of genes and its biological implications,”Important Advances in Oncology, 1994, DeVita, V.T., et al. (Eds.), Lippincott Company, Philadelphia, PA, 21-36.
Chiu, M.I., et al., “Murine and bovine blue cone pigment genes: cloning and characterization of two new members of the S family of visual pigments,”Genomics, 1994, 21, 440-443.
Chomczynski, P., et al., “Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction,”Analyt. Biochem., 1987, 162, 156-159.
Cline, M.J., “Perspectives for gene therapy: inserting new genetic information into mammalian cells by physical techniques and viral vectors,”Pharmac. Thera., 1985, 29, 69-92.
Daemen, F.J.M., “Vertebrate rod outer segment membranes,”Biochem. Biophys. Acta, 1973, 300, 255-288.
De la Salle, H., et al., “Homozygous human TAP peptide transporter mutation in HLA class I deficiency,”Science, 1994, 265, 237-241.
Dean, M., et al., “Evolution of ATP-binding cassetter transporter genes,”Curr. Opin. Genet.&Dev., 1995, 5, 779-785.
Dean, M., et al., “Mapping and sequencing of two yeast genes belonging to the ATP-binding cassetter superfamily,”Yeast, 1994, 10, 377-383.
Deveraux, J., et al., “A comprehensive set of sequence analysis programs for the VAX,”Nucleic Acids Res., 1984, 12, 387-395.
Dowling, J.E., “Chemistry of visual adaptation in the rat,”Nature, 1960, 188, 114-118.
Dryja, T.P., et al., “Molecular genetics of retinitis pigmentosa,”Hum. Mol. Genet., 1995, 4, 1739-1743.
Eagle, R.C., Jr., et al., “Retinal pigment epithelial abnormalities in fundus flavimaculatus,”Ophthalmology, 1980, 87, 1189-1200.
Feeney, L., “Lipofuscin and melanin of human retinal pigment epithelium,”Invest. Ophthalmol. Vis. Sci., 1978, 17, 583-600.
Feng, D.F., et al., “Progressive sequence alignment as a prerequisite to correct phylognetic trees,”J. Mol. Evol., 1987, 25, 351-360.
Fishman, G.A., “Fundus flavimaculatus,”Arch. Ophthalmol., 1976, 94, 2061-2067.
Fong, S.L., et al., “Purification and characterization of a retinol-binding glycoprotein synthesized and secreted by bovine neural retina,”J. Biol. Chem., 1984, 259, 6534-6542.
Frohman, M.A., In:PCR Protocols: A Guide to Methods and Applications, 1990, Academic Press, NY.
Gass, J.D.M., “Stargardt's disease (fundus flavimaculatus),”Stereoscopic Atlas of macular Diseases: Diagnosis and Treatment, 1987, 1, 3rdEd., C. V. Mosby Co., St. Louise, MO, 256-261.
Gerber, S., et al., “A gene for late-onset fundus flavimaculatus with macular dystrophy maps to chromosome 1p13,”Am. J. Hum. Genet., 1995, 56, 396-399.
Gerber, S., et al., “Complete exon-intron structure of the retina-specific ATP binding transporter gene (ABCR) allows the identification of novel mutations underlying startgardt disease,”Genomics, 1998, 48, 139-142.
Glavac, D., et al., “Optimization of the single-strand conformation polymorphism (SSCP) technique for detection of point mutations,”Hum. Mutat., 1993, 2, 404-414.
Hayes, K.C., “Retinal degeneration in monkeys induced by deficiencies of vitamine E or A,”Invest. Ophthalmology, 1974, 13, 499-510.
Hettema, E.H., et al., “The ABC transporter proteins Pat1 and Pat2 are required for import of long-chain fatty acids into peroxisomes ofSaccharomces cerevisiae,” EMBO J., 1996, 15, 3813-3822.
Hoying, C.B., et al., “Genetic fine mapping of the gene for recessive stargardt disease,”Hum. Genet., 1996, 98, 500-504.
Hyde, S.C., et al., “Structural model of ATP-binding proteins associated with cystic fibrosis, multidrug resistance and bacterial transport,”Nature, 1990, 346, 362-365.
Innis, et al.,PCR Protocols, Academic Press, Inc., San Diego, CA, 1990.
Klein, B.A., et al, “Fundud flavimaculatus: clinical, functional and histopathic observations,”Am. J. Ophthalmol., 1967, 64, 3-23.
Klugbauer, N., et al, “Primary structure of a novel ABC transporter with a chromosomal localization on the band encoding the multidrug resistance-associated protein,”FEBS Letts., 1996, 391, 61-65.
Kuwano, Y., et al., Molecular cloning and nucleotide sequence of DNA complementary to ra
Allikmets Rando
Anderson Kent L.
Dean Michael
Leppert Mark
Lewis Richard A.
Baylor College of Medicine
John Hopkins University
Kaushal Sumesh
The United States of America as represented by the Department of
University of Utah Research Foundation
LandOfFree
Methods of screening and diagnostics using ATP-binding... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Methods of screening and diagnostics using ATP-binding..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods of screening and diagnostics using ATP-binding... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3805394