Methods of observing autonomic neural stimulation and diagnosing

Details Methods of observing autonomic neural stimulation and diagnosing Methods of observing autonomic neural stimulation and diagnosing

1988-12-05

1990-10-02

Jaworski, Francis

Surgery

Truss

Pad

128700, 128716, A61B 502

Patent

active

049601296

ABSTRACT:
Methods of isolating individual neural impulses are disclosed. In a preferred embodiment, methods of observing the response of the heart to autonomic neural control are presented. The present invention is used to observe cardioventilatory phase-locking. The noninvasive technique disclosed are a useful clinical tool for observing phase locking as diagnostic of physiological disorders which result from autonomic neural dysfunction. The methods of observation disclosed also are applicable to the isolation of other neural impulses. An understanding of cardioventilatory interaction is obtained by plotting highly accurate heartbeat-interval (hbi) time series data versus ventilator phase. The data displays created by the methods of the present invention show structure whose features are reproducible over time and across subjects. These structures are attributable to the effect of individual neural impulses from the autonomic nervous system which influence the cardiac pacemaker. The absence of neural function has been correlated to various physiological dysfunctions.

REFERENCES:
patent: 4573472 (1986-05-01), Ito
patent: 4729381 (1988-03-01), Harada et al.
patent: 4777960 (1988-10-01), Berger
patent: 4781201 (1988-11-01), Wright et al.
patent: 4862897 (1989-09-01), Eisenberg et al.

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