Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Radical -xh acid – or anhydride – acid halide or salt thereof...
Patent
1993-06-11
1995-06-27
Lone, Werren B.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Radical -xh acid, or anhydride, acid halide or salt thereof...
514310, A01N 3700, A61K 3119
Patent
active
054280702
ABSTRACT:
Atherogenesis and restenosis are treated by long term administration of physiologically acceptable compounds which enhance the level of endogenous nitric oxide in the host. Alternatively, or in combination, other compounds may be administered which provide for short term enhancement of nitric oxide, either directly or by physiological processes. In addition, cells may be genetically engineered to provide a component in the synthetic pathway to nitric oxide, so as drive the process to enhance nitric oxide concentration, particularly in conjunction with the administration of a nitric oxide precursor.
REFERENCES:
Andrews et al., "Low-density Lipoproteins inhibit endothelium-dependent Relaxation in Rabbit Aorta", Nature, 327:237-239 (1987).
Bath et al., "Nitric Oxide and Prostacyclin: Divergence of Inhibitory Effects on Monocyte Chemotaxis and Adhesion to Endothelium in Vitro", Arteriosclerosis and Thrombosis, 11(2):254-260 (1991).
Cooke, "Endothelial Dysfunction in Disease States", Current Opinion in Cardiology, 5:637-644 (1990).
Drexler et al., "Correction of Endothelial Dyfunction in Coronary Microcirculation of Hypercholesterolaemic Patients", The Lancet, 338:1546-1550 (1991).
Garg and Hassid, "Nitric Oxide-generating Vasodilators and 8-Bromo-Cyclic Guanosine Monophosphate Inhibit Mitogenesis and Proliferation of Cultured Rat Vascular Smooth Muscle Cells", J. Clin. Invest., 83:1774-1777 (1989).
Girerd et al., "L-Arginine Augments Endothelium-Dependent Vascodilation in Cholesterol-Fed Rabbits", Circulation Research, 67(6):1301-1308 (1990).
Heistad et al., "Augmented Responses to Vasoconstrictor Stimuli in Hypercholesterolemic and Atherosclerotic Monkeys", Circulation Research, 54(6)711-718 (1984).
Kubes et al., "Nitric Oxide: An Endogenous Modulator of Leukocyte Adhesion", Proc. Natl. Acad. Sci. USA, 88:4651-4655 (1991).
Kugiyama et al., "Impairment of Endothelium-dependent Arterial Relaxation by Lysolectithin in Modified Low-density Lipoproteins", Nature, 344:160-162 (1990).
Kuo et al., "Pathophysiological Consequences of Atherosclerosis Extend Into the Coronary Microcirculation: Restoration of Endothelium-dependent Responses by L-Arginine", Circulation Research, 70(3):465-476 (1992).
Lefer et al., "Role of Endothelium-derived Relaxing Factor as a Cardioprotective Agent in Myocardial Ishemia", Basil, Karger, pp. 190-197 (1990).
Minor et al., "Diet-induced Atherosclerosis Increases the Release of Nitrogen Oxides from Rabbit Aorta", J. Clin. Invest., 86:2109-2116 (1990).
Mitchell et al., "Native LDL Inhibits the Release of Endothelial Derived Relaxing Factor by Reducing the Activity of Endothelial Nitric Oxide Synthase", (Abstract), J. Vasc. Res., 29:169 (1992).
Pohl and Busse, "EDRF Increases Cyclic GMP in Platelets During Passage Through the Coronary Vascular Bed", Circulation Research, 65(6):1798-1803 (1989).
Radomski et al., "Comparative Pharmacology of Endothelium-derived Relaxing Factor, Nitric Oxide and Prostacyclin in Platelets", Br. J. Pharmacol., 92:181-187 (1987).
Ross, "The Pathogenesis of Atherosclerosis--an Update", The New England Journal of Medicine, 314(8):488-500 (1986).
Rossitch, Jr. et al., "L-Arginine Normalizes Endothelial Function in Cerebral Vessels from Hypercholesterolemic Rabbits", J. Clin. Invest., 87:1295-1299 (1991).
Stamler et al., "N-Acetylcysteine Potentiates Platelet Inhibition by Endothelium-derived Relaxing Factor", Circulation Research, 65(3):789-795 (1989).
Tanner et al., "Oxidized Low Density Lipoproteins Inhibit Relaxations of Porcine Coronary Arteries: Role of Scavenger Receptor and Endothelium-derived Nitric Oxide", Circulation, 83(6):2109-2116 (1991).
Tomita et al., "Rapid and Reversible Inhibition by Low Density Lipoprotein of the Endothelium-dependent Relaxation to Hemostatic Substances in Porcine Coronary Arteries", Circulation Research, 66(1):18-27 (1990).
Weidinger et al., "Persistent Dysfunction of Regenerated Endothelium After Balloon Angioplasty of Rabbit lliac Artery", Circulation, 81(5):1667-1679 (1990).
Yamamoto et al., "Videomicroscopic Demonstration of Defective Cholinergic Arteriolar Vascodilation in Atherosclerotic Rabbit", J. Clin. Invest., 81:1752-1758 (1988).
Cooke John P.
Dzau Victor J.
Gibbons Gary H.
Lone Werren B.
Rowland Bertram I.
The Board of Trustees of the Leland Stanford Junior University
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