Methods of manufacture of nitrile-containing glucuronic acid con

Details Methods of manufacture of nitrile-containing glucuronic acid con Methods of manufacture of nitrile-containing glucuronic acid con

1978-10-13

1984-01-03

Brown, Johnnie R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 41, 536 185, 536 553, 536124, 424180, A61K 3170, C07H 1518

Patent

active

044243480

ABSTRACT:
Mandelonitrile-.beta.-D-glucuronic acid is produced by condensing a mandelic amide with a tri-O-acetyl methyl ester of glucuronic acid and then reacting the product with acetic anhydride to produce the tri-O-acetyl methyl ester of mandelonitrile-.beta.-D-glucuronic acid. The protecting acetyl groups may be removed and the barium salt formed by reacting with barium hydroxide, which salt, when treated with sulfuric acid, will yield the mandelonitrile-.beta.-D-glucuronic acid. This compound, as well as methacrylonitrile .beta.-D-glucuronic acid may be used in the treatment of bacterial infections having .beta.-glucuronidase activity.

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