Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Particulate form
Patent
1999-01-06
2000-05-30
Bawa, Raj
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Particulate form
424494, A61K 914
Patent
active
060688580
ABSTRACT:
The present invention describes formulations of nanoparticulate HIV protease inhibitors comprising a cellulosic surface stabilizer. The nanoparticulate formulations have an increased rate of dissolution in vitro, an increased rate of absorption in vivo, a decreased fed/fasted ratio variability, and a decreased variability in absorption. The present invention is also directed to methods of making the novel formulations. In particular, nanoparticulate formulations of HIV type 1 (HIV-1) and type 2 (HV-2) protease inhibitors are described.
REFERENCES:
patent: 5145684 (1992-09-01), Liversidge et al.
patent: 5399363 (1995-03-01), Liversidge et al.
patent: 5429824 (1995-07-01), June
patent: 5518187 (1996-05-01), Bruno et al.
patent: 5518738 (1996-05-01), Eickhoff et al.
patent: 5622938 (1997-04-01), Wong
"The Protease Inhibitors Backgrounder," Office of Special Health Issues and Division of Antiviral Drug Products, Food and Drug Administration (Dec. 4, 1998).
Physicians' Desk Reference,53.sup.rd Edition, "Invirase.TM.; saquinavir mesylate," pp. 2685-2688 (Medical Economics Co., 1999).
Physicians' DeskReference, 53.sup.rd Edition, "Fortovase.TM.; saquinavir," pp. 2675-2681 (Medical Economics Co., 1999).
Physicians' DeskReference, 53.sup.rd Edition, "Norvir.TM.; ritonavir," 464-469 (Medical Economics Co., 1999).
Physicians' Dest Reference, 53.sup.rd Edition, "Viracept.RTM.; nelfinavir," 484-487 (Medical Economics Co., 1999).
M Markowitz, "Protease Inhibitors" pp. 2, 7 (International Association of Physicians in AIDS Care, Sept. 1997).
Physicians' DeskReference, 53.sup.rd Edition, "Crixivan.RTM.; indinavir," 1762-1766 (Medical Economics Co., 1999).
DeGaravilla et al. Chemical Abstracts, vol. 126, #247686, (1996).
Ruddy et al., Chemical Abstracts, vol. 125, #257225 (1996).
Structure-Based Design of Novel HIV Protease Inhibitors: Sulfonamide-Containing 4-Hydroxycoumarins and 4-Hydroxy-2-pyrones as Potent Non-Peptidic Inhibitors, Suvit Thaisrivongs, et al., J. Med. Chem, 1996, 39, 2400-2410.
Engers David A.
Liversidge Gary G.
Roberts Mary E.
Ruddy Stephen B.
Wong Sui-Ming
Bawa Raj
Elan Pharma International Limited
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