Methods of identifying compounds that modulate IL-4...

Chemistry: analytical and immunological testing – Biospecific ligand binding assay

Reexamination Certificate

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C436S503000, C424S085200, C514S012200

Reexamination Certificate

active

07141434

ABSTRACT:
The present provides compounds capable of modulating IL-4 receptor-mediated IgE production, as well as IL-4 induced processes associated therewith, methods and kits for identifying such compounds that utilize an adenosine kinase as a surrogate analyte and methods of using the compounds in a variety of in vitro, in vitro and ex vivo contexts.

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Hikida, M., et al., “Requirements of a Costimulus of IL-4 Induced IgE Class Switching in Murine B Cells Activated Via Antigen Receptors”,The Journal of Immunology, 1996, 156:2730-2736.
Izuhara, K., et al., “Atopy and the Human IL-4 Receptor a Chain”,J Allergy Clin Immunol, Jul. 2000, 106:S65-71.
Richards, M.L., et al., “Analysis of the Promoter Elements Necessary for IL-4 and Anti-CD40 Antibody Induction of Murine FcεRII (CD23)”,Journal of Immunology, 1997, 158:263-272.

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