Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving hydrolase
Reexamination Certificate
2008-07-22
2008-07-22
Prouty, Rebecca E. (Department: 1652)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving hydrolase
C435S195000, C536S023200, C536S023500
Reexamination Certificate
active
10493057
ABSTRACT:
The present invention identified OVARC1000473 (SEQ ID NO: 1) and NT2RM1000377 (SEQ ID NO: 3) as clones showing suppression of CREB activation by forskolin, and provides evaluation methods using these genes, and/or proteins encoded by these genes. Furthermore, these proteins were found to enhance cell damage. Compounds that can be screened based on the evaluation methods of this invention are useful as agents for inhibiting the CREB dephosphorylation reaction, agents for suppressing enhancement of cell damage, and preventive and therapeutic agents for memory disorders and/or neurodegenerative disorders.
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Alignment of SEQ ID No. 4 with protein Accession No. AAB94018.
Alignment of SEQ ID No. 4 with human protein Accession No. Q9H9Z5.
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Arakawa Hiroyuki
Kita Yasuhiro
Morita Masahiko
Nishimura Shintaro
Satoh Susumu
Astellas Pharma Inc.
Oblon & Spivak, McClelland, Maier & Neustadt P.C.
Prouty Rebecca E.
Walicka Malgorzata A.
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