Methods of diagnosing Alzheimer's disease

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

Reexamination Certificate

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C435S007100, C435S007900, C436S501000, C436S503000

Reexamination Certificate

active

07897361

ABSTRACT:
Methods and compositions relating to Alzheimer's disease are provided. Specifically, proteins that are differentially expressed in the Alzheimer's disease state relative to their expression in the normal state are provided. Proteins associated with Alzheimer's disease are identified and described. Methods of diagnosis of Alzheimer's disease using the differentially expressed proteins are also provided, as are methods for the identification and therapeutic use of compounds for the prevention and treatment of Alzheimer's disease.

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Tilleman, Kelly et al., “Differential expression of brain proteins in glycogen synthase kinase-3beta transgenic mice: A proteomics point of view”, Proteomics, 2(1): 94-104 (2002).
Andreasen, Niels et al., “Cerebrospinal fluid beta-amyloid(1-42) in Alzheimer disease: Differences between early- and late-onset Alzheimer disease and stability during the course of disease”, Archives of Neurology, 56(6): 673-680 (1999).
Kanai et al., “Longitudinal Study of Cerebrospinal Fluid Levels of Tau, ABeta1-40, and ABeta1-42(43) in Alzheimer's Disease: A Study in Japan”, Annals of Neurology, 44(1): 17-26 (1998).

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