Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1994-12-01
1997-07-08
Wilson, James O.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
514 45, 514825, 514885, 514886, A61K 3170
Patent
active
056461283
ABSTRACT:
Novel compounds which selectively inhibit adenosine kinase and methods of preparing adenosine kinase inhibitors are provided. Also provided are methods of treating various inflammatory conditions, including arthritis and SIRS, which may be ameliorated by increased local concentrations of adenosine using adenosine kinase inhibitors.
REFERENCES:
Biochemical Pharmacology, vol. 28, pp. 501-510, Received 4 May 1978; Accepted 22 Jun. 1978 (Author: Agarwal, et al.).
Molecular Pharmacology, vol. 7, pp. 663-673; Received Jul. 20, 1971 (Author: Divekar and Hakala).
J. Med. Chem. 1984, vol. 27, pp. 285-292; Received May 9, 1983 (Author: Bergstrom, et al.).
M.G. Stout et al., J. Org. Chem., vol. 33, No. 3, Mar. 1968, pp. 1219-1225.
Y. Tominaga et al., J. Heterocyclic Chem., 27, pp. 647-660 (1990).
I. Chut et al., J. Med. Chem., 1975 vol. 18, No. 2, pp. 161-165.
H.B. Cottam et al., J. Med. Chem., 1984, 27, pp. 119-1127.
J.S. Pudlo et al., J. Med. Chem., 1990, 33, pp. 1984-1992.
C.W. Noell et al., J. Heterocyclic Chem., 1964, 1, pp. 34-41.
M. Ikehara et al., Tetrahedron, vol. 26, pp. 5757-5763 (1970).
J. Davoll, J. Chem. Soc., 1960, pp. 131-138.
B.C. Hinshaw et al., J. Heterocyclic Chem., vol. 6, pp. 215-221 (1969).
H. Rosemeyer et al., Helvetica Chimica Acta, vol. 71, pp. 1573-1585, (1988).
J.R. Synder et al., Carbohydrate Research, 163 (1987), pp. 169-188.
R.A. Carboni et al., J. Amer. Chem. Soc., vol. 80 (1958), pp. 2838-2840.
E.C. Taylor et al., J. Org. Chem., vol. 31 (1966), pp. 342-343.
S. Kobayashi, Chem. Pharm. Bull., 21(5) (1973), pp. 941-951.
Browne Clinton E.
Bullough David A.
Castellino Angelo J.
Erion Mark D.
Firestein Gary S.
Gensia Inc.
Wilson James O.
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