Methods for the treatment of infection caused by Hepatitis B vir

Details Methods for the treatment of infection caused by Hepatitis B vir Methods for the treatment of infection caused by Hepatitis B vir

1992-10-09

1995-07-11

Robinson, Douglas W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514 49, A61K 31505

Patent

active

054321654

ABSTRACT:
The present invention relates to pharmaceutical compositions useful for the treatment of subjects suffering from an infection or disease caused by the hepatitis B virus (HBV). In particular, it has been discovered that the administration of low dosage amounts of 1-(2'-deoxy-2'-fluoro-.beta.-D-arabinofuranosyl)-5-iodouracil (FIAU) to humans chronically infected with HBV is effective to reduce drastically circulating markers associated with HBV. The present invention is also directed to methods of the preparation of pharmaceutical antiviral compositions.

REFERENCES:
patent: 4211773 (1980-07-01), Lopez et al.
patent: 4594339 (1986-06-01), Lopez et al.
patent: 4666892 (1987-05-01), Fox et al.
Fried, M. W. et al.; Hematology, vol. 16, No. 4 Pt. 2 (1992), p. 127 A.
Hantz, O. et al.; Antiviral Research, vol. 4, No. 4 (1984), pp. 187-199.

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