Methods for the manufacture of cephems

Details Methods for the manufacture of cephems Methods for the manufacture of cephems

1990-01-08

1996-12-10

Ford, John M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

540228, C07D50106, C07D50156

Patent

active

055832164

ABSTRACT:
Provided is a process for preparing a cephem compound of the formula: ##STR1## wherein R.sup.3 is hydrogen or methoxy, R.sup.4 is hydrogen or a residue of a nucleophilic compound, R.sup.5 is hydroxyl or a protected hydroxyl, and R.sup.8 is hydrogen or halogen, or a pharmaceutically acceptable salt or ester thereof, which comprises introducing an acyl group of the formula: ##STR2## wherein R.sup.5 and R.sup.8 are as defined above into the amino group of the molecule of the formula: ##STR3## wherein R.sup.3 and R.sup.4 are as defined above or a salt or ester thereof.

REFERENCES:
patent: 3167549 (1965-01-01), Hoover
patent: 3338897 (1967-08-01), Takano et al.
patent: 3360515 (1967-12-01), Takano et al.
patent: 4024133 (1977-05-01), Cook et al.
patent: 4024134 (1977-05-01), Cook et al.
Cephalosporins & Penicillins pp. 83-91 (1972) Academic Press.

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