Methods for the identification of antiviral compounds

Details Methods for the identification of antiviral compounds Methods for the identification of antiviral compounds

2007-01-16

2007-01-16

Campell, Bruce R. (Department: 1648)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving virus or bacteriophage

C435S004000, C435S029000, C435S032000, C435S325000, C435S366000

Reexamination Certificate

active

10698086

ABSTRACT:
The present invention provides novel methods for determining whether a compound influences a phase in the life cycle of a virus comprising providing a cell with the compound and with at least a fragment of the virus sufficient for performing the phase and determining whether the phase is influenced in the cell, the cell comprising a nucleic acid encoding an adenovirus early protein or a functional part, derivative and/or analogue of the adenovirus early protein. In another aspect, the invention provides the use of a cell, the cell comprising nucleic acid encoding an adenovirus early protein, for screening a library of compounds for the presence of a compound capable of influencing a phase in the life cycle of a virus capable of entering the cell. The invention also provides novel methods for identifying a compound with antiviral activity comprising providing a cell with at least a fragment of a virus, the fragment capable of performing a step in the life cycle of the virus, providing the cell with a compound and determining whether the compound is capable of influencing the step in the life cycle of the virus, wherein the cell comprises a nucleic acid encoding an adenovirus early protein or a functional part, derivative and/or analogue of the adenovirus early protein.

REFERENCES:
patent: 5994128 (1999-11-01), Fallaux et al.
patent: 6033908 (2000-03-01), Bout et al.
patent: 6071744 (2000-06-01), Scholl et al.
patent: 6200745 (2001-03-01), Kreider et al.
patent: 6218105 (2001-04-01), Hall et al.
patent: 2002/0076789 (2002-06-01), Homa et al.
patent: 2006/0051747 (2006-03-01), Pau et al.
patent: 2006/0063261 (2006-03-01), Pau et al.
patent: 0978566 (2000-02-01), None
patent: WO 91/15573 (1991-10-01), None
patent: WO 97/00326 (1997-01-01), None
patent: WO 99/51776 (1999-10-01), None
patent: WO 99/64582 (1999-12-01), None
patent: WO 00/63403 (2000-10-01), None
patent: WO 01/38362 (2001-05-01), None
patent: WO 02/090982 (2002-11-01), None
Lin et al., Journal of Virological Methods, vol. 88 No. 2, pp. 219-225 (Aug. 2000).
Spector et al., Journal of Virology, vol. 72 No. 9, pp. 6979-6987 (Sep. 1998).
Cotarelo et al., Journal of Antimicrobial Chemotherapy, vol. 44 No. 5, pp. 705-708 (Nov. 1999).
PCT International Search Report, PCT/NL02/00296, dated Oct. 7, 2002.
PCT International Preliminary Examination Report, PCT/NL02/00296, dated Mar. 13, 2003, 2 pages.
PCT Written Opinion, PCT/NL02/00296, Dec. 19, 2002.
Gallimore et al., Transformation of Human Embryo Retinoblasts with Simian Virus 40, Adenovirus and ras Oncogenes, Anticancer Research, 1986, pp. 499-508, vol. 6.
Lewin, Benjamin, Genes V, 1994, p. 1184, Oxford University Press and Cell Press.

Affiliated with

Also associated with

Rating

Methods for the identification of antiviral compounds does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Methods for the identification of antiviral compounds, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods for the identification of antiviral compounds will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3760863