Methods for the early diagnosis of ovarian cancer

Details Methods for the early diagnosis of ovarian cancer Methods for the early diagnosis of ovarian cancer

2005-04-05

2005-04-05

Harris, Alana M. (Department: 1642)

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

Primate cell, per se

C435S325000, C435S343200, C435S363000, C514S001000, C514S002600, C514S008100, C514S013800, C514S014800, C514S015800, C514S017400, C514S018700, C514S019300, C514S023000, C514S054000, C530S300000

Reexamination Certificate

active

06875609

ABSTRACT:
The disclosed nucleic acid primer sets, used in combination with quantitative amplification (PCR) of tissue cDNA, can indicate the presence of specific proteases in a tissue sample. Specifically, the present invention relates to expression of hepsin protease. The detected proteases are themselves specifically over-expressed in certain cancers, and the presence of their genetic precursors may serve for early detection of associated ovarian and other malignancies, and for the design of interactive therapies for cancer treatment.

REFERENCES:
patent: 6232456 (2001-05-01), Cohen et al.
Paglia et al. Murine Dendritic Cells Loaded In Vitro with Soluble Protein Prime Cytotoxic T Lymphocytes against Tumor Antigen In Vivo. J. Exp. Med 183: 317-322, Jan. 1996.*
Gura. Systems for Identifying New Drugs are Often Faulty, Science 278:1041 and 1042, Nov. 7, 1997.*
Jain. Barriers to Drug Delivery in Solid Tumors. Scientific American 271(1): 58-65, Jul. 1994.*
Sequence from U.S. patent 6,232,456 issued May 2001.

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