Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,...
Patent
1994-06-03
1999-01-12
Eisenschenk, Frank C.
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
4241431, 4241541, 5303871, 53038822, 5303887, 53038875, 435383, A61K 39395, C07K 1600
Patent
active
058583580
ABSTRACT:
Methods for inducing a population of T cells to proliferate by activating the population of T cells and stimulating an accessory molecule on the surface of the T cells with a ligand which binds the accessory molecule are described. T cell proliferation occurs in the absence of exogenous growth factors or accessory cells. T cell activation is accomplished by stimulating the T cell receptor (TCR)/CD3 complex or the CD2 surface protein. To induce proliferation of an activated population T cells, an accessory molecule on the surface of the T cells, such as CD28 or CD9, is stimulated with a ligand which binds the accessory molecule. The T cell population expanded by the method of the invention can be genetically transduced and used for immunotherapy or can be used in methods of diagnosis.
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Freeman Gordon J.
Gray Gary S.
June Carl H.
Nabel Gary J.
Rennert Paul D.
Dana-Farber Cancer Institute
Eisenschenk Frank C.
Mandragouras Amy E.
The Regents of the University of Michigan
The United States of America as represented by the Secretary of
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