Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Radical -xh acid – or anhydride – acid halide or salt thereof...
Patent
1997-10-03
2000-06-27
Spivack, Phyllis G.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Radical -xh acid, or anhydride, acid halide or salt thereof...
514 78, 514547, A61K 31202, A61K 31225, A61K 31685
Patent
active
060807873
ABSTRACT:
Enteral formulas that contain long-chain polyunsaturated fatty acids (PUFAs), as arachidonic acid (AA) and docosahexaenoic acid (DHA) that are essentially free of cholesterol, are described. More particularly, the invention relates to methods for reducing the incidence of necrotizing enterocolitis by administering compositions which provide .omega.-6 and .omega.-3 long chain PUFAs, phospholipids and/or choline. Compositions from egg yolk lipids are presently preferred as they contain .omega.-6 and .omega.-3 long chain PUFAs and are predominantly in a phosphtidylcholine form. This is believed to provide a synergistic effect.
REFERENCES:
patent: 4670285 (1987-06-01), Clandinin
patent: 4784861 (1988-11-01), Gori
patent: 4918063 (1990-04-01), Lichtenberger
patent: 4950656 (1990-08-01), Lichtenberger
patent: 5032585 (1991-07-01), Lichtenberger
patent: 5043329 (1991-08-01), Lichtenberger
patent: 5374657 (1994-12-01), Kyle
patent: 5550156 (1996-08-01), Kyle
patent: 5658767 (1997-08-01), Kyle
Teruya, J. et al., Mode of Transport of Fatty Acid to Endothelial Cell Influences Intracellular Fatty Acid Metabolism, Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts (USA) J. Lipid Res. Feb. 1995: 36(2): 266-76.
Neu, Pediatr. Clin. North. Am., Apr., 1996, 43(2): pp. 409-432.
Flageole, et al., Necrotizing Enterocolitis of the Newborn, Review for the Clinician, Union-Med-Can.1991, Sep.-Oct.; 120(5): in French.
Caplan, et al., Role of Platelet Activating Factor and Tumor Necrosis Factor-Alpha in Neonatal Necrotizing Enterocolitis, Journal of Pediatrics, Jun., 1990, pp. 960-964.
Kliegman, et al., Clostridia as Pathogens in Neonatal Necrotizing Enterocolitis, The Journal of Pediatrics, Aug., 1979, pp. 287-289.
Ostertag, et al., Early Enteral Feeding Does Not Affect the Incidence of Necrotizing Enterocolitis, Pediatrics, vol. 77, No. 3, Mar. 1986, pp. 275-280.
Bell, et al., Neonatal Necrotizing Enterocolitis, Annals of Surgery, vol. 187, Jan., 1978, No. 1, pp. 1-7.
Eyal, et al., Necrotizing Enterocolitis in the Very Low Birth Weight Infant: Expressed Breast Milk Feeding Compared with Parenteral Feeding, Archives of Disease in Childhood, 1982, 57, pp. 274-276.
Finer, et al., Vitamin E and Necrotizing Enterocolitis, Pediatrics, vol. 73, No. 3, Mar., 1984, pp. 387-393.
Brown, et al., Preventing Necrotizing Enterocolitis in Neonates, JAMA, Nov. 24, 1978, vol. 240, No. 22, pp. 2452-2454.
Kosloske, Pathogenesis and Prevention of Necrotizing Enterocolitis: A Hypothesis Based on Personal Observation and a Review of the Literature, Pediatrics, vol. 74, No. 6, Dec., 1984, pp. 1086-1092.
Di Lorenzo, et al., Use of L-Arginine in the Treatment of Experimental Necrotizing Enterocolitis, Journal of Pediatric Surgery, vol. 30, No. 2 Feb. 1995, pp. 235-241.
Di Lorenzo, et al., An Intraluminal Model of Necrotizing Enterocolitis in the Developing Neonatal Piglet, Journal of Pediatric Surgery, vol. 30, No. 8, Aug. 1995, pp. 1138-1142.
Velasquez, et al., Fatty Acid-Induced Injury In Developing Piglet Intestine: Effect of Degree of Saturation and Carbon Chain Length, Pediatric Research, vol. 33, No. 6, 1993, pp. 543-547.
Bell, et al., Perinatal Dietary Supplementation with a Commercial Soy Lecithin Preparation: Effects on Behavior and Brain Biochemistry in the Developing Rat, Developmental Psychobiology, 18(5), pp. 383-394, 1985.
Baker, et al., The Hydrolysis of Natural Phosphatidylethanolamines by Phospholipase A.sub.2 From Rat Serum: A Degree of Selectivity is Shown for Docosahexaenoate Release, Biochimica et Biophysica Acta, 1125 (1992), pp. 56-61, 1992, Elsevier Science Publishers B.V.
Smith, William, Prostanoid Biosynthesis and Mechanisms of Action, Editorial Review, pp. F181-F191, 1992.
van Beek, et al., Nutrition in the Neonate, Neonatology and Perinatology, Current Science ISSN 1040-8703, pp. 146-151 (1995).
Benson John D.
Borror David A.
Carlson Susan E.
Diodato David V.
Dohnalek Margaret H.
Abbott Laboratories
Brainard Thomas D.
Spivack Phyllis G.
LandOfFree
Methods for reducing the incidence of necrotizing enterocolitis does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Methods for reducing the incidence of necrotizing enterocolitis, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods for reducing the incidence of necrotizing enterocolitis will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1785194