Methods for proliferating and differentiating B cells with high

Details Methods for proliferating and differentiating B cells with high Methods for proliferating and differentiating B cells with high

1995-04-28

1998-10-06

Feisee, Lila

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

Method of regulating cell metabolism or physiology

435 2, 435325, 435366, 4353722, 435375, C12N 502, C12N 508

Patent

active

058175164

ABSTRACT:
The present invention provides methods of proliferating B cells as a means of obtaining large numbers of B cells. The present invention further provides methods of differentiating a proliferating B cell population to antibody producing cells.

REFERENCES:
1. Hollenbaugh et al. EMBO J. 11: 4313-4321 (1992).
2. Spriggs et al. J Exp Med 176: 1543-1550 (1992).
1 Castle et al. FAJEB J. 8: A 1012 (1994).
Armitage et al., "Human B Cell Proliferation and Ig Secretion Induced by Recombinant CD40 Ligand Are Modulated by Soluble Cytokines", J. Immunology, vol. 150, No. 9: 3671-3680 (1993) (May issue).
Armitage et al., "CD40L: A Multifunctional Ligand", Sem. Immunol. 5:401-412 (1993) (Dec. issue).
Marshall et al., "The Molecular Basis for T Cell Help in Humoral Immunity: CD40 and Its Ligand, gp39", J. Clin. Immunol. 13(3): 165-174 (1993) (Jun. issue).
Maliszewski et al., "Recombinant CD40 Ligand Stimulation of Murine B Cell Growth and Differentiation: Cooperative Effects of Cytokines", Eur. J. Immunol. No. 5: 23:1044-1049 (1993) (May issue).
1. Kehry et al. "B Cell Activation Mediated By Interactions With Membranes From Helper Cells", in Mechanisms of Lymphocyte Activation and Immune Regulation IV: Cellular Communications, pp. 139-148 (S. Gupta et al. Eds., 1992).

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