Methods for producing members of specific binding pairs

Details Methods for producing members of specific binding pairs Methods for producing members of specific binding pairs

2004-03-18

2010-06-08

Steele, Amber D. (Department: 1639)

Combinatorial chemistry technology: method, library, apparatus

Method of screening a library

By measuring the ability to specifically bind a target...

C435S005000, C435S007100

Reexamination Certificate

active

07732377

ABSTRACT:
A member of a specific binding pair (sbp) is identified by expressing DNA encoding a genetically diverse population of such sbp members in recombinant host cells in which the sbp members are displayed in functional form at the surface of a filamentous bacteriophage particle containing DNA encoding the sbp member, wherein the sbp member has a binding domain that consists of a dAb fragment. The displayed sbps may be selected by affinity with a complementary sbp member, and the DNA recovered from selected filamentous bacteriophage particles for expression of the selected sbp members.

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