Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1985-05-17
1986-05-20
Schain, Howard E.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
424 89, 424101, 530387, A61K 3912, A61K 3942, A61K 3706, C07K 320
Patent
active
045900027
ABSTRACT:
Methods for producing from human plasma or serum, human gamma globulin free of hepatitis-B-virus infectivity and products resulting therefrom. Specifically provided are ion exchange resin/buffer systems capable of effectively removing the virus.
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Walsh, T. J. and O'Riordan, J. P., A Review of the Production and Clinical Use of Intravenous Anti-D Immunoglobulin, Irish Med. J. 75, 243-244 (1982).
Baumstark, J. S. et al., A Preparative Method for the Separation of 7S Gamma Globulin from Human Serum, Archives of Biochemistry and Biophysics 108:514-522 (1964).
Webb, A. J., A 30-Minute Preparative Method for Isolation of IgG from Human Serum, Vox Sang 23:279-290 (1972).
Stanworth, D. R., A Rapid Method for Preparing Pure Serum Gamma-Globulin, Nature 188:156-157 (1960).
Harris, et al., Freedom from Transmission of Hepatitis-B of Gamma-Globulin and Heat-Inactivated Plasma Protein Fraction Prepare from Contaminated Human Plasma by Fractionation with Solid-Phase Polyelectrolytes, Vox Sang 36:129-136 (1979).
J. M. Curling, Methods of Plasma Protein Fractionation, Pharmacia Fine Chemicals, Uppsala, Sweden, 1980 (Academic Press).
Kaplan Paul M.
Padvelskis John V.
Zolton Raymond P.
Kean Leonard
Ortho Diagnostic Systems Inc.
Schain Howard E.
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