4-amino-n-(4-methyl-4-piperidinyl)-2-methoxybenzamides

Details 4-amino-n-(4-methyl-4-piperidinyl)-2-methoxybenzamides 4-amino-n-(4-methyl-4-piperidinyl)-2-methoxybenzamides

1995-10-27

1997-11-25

Chang, Ceila

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546224, A61K 31445, C07D21156

Patent

active

056913583

ABSTRACT:
Piperidinyl substituted benzamides of formula ##STR1## the pharmaceutically acceptable acid addition salts thereof and the stereoisomeric forms thereof, wherein R.sup.1 is hydrogen or halo; R.sup.2 is halo; R.sup.3 is hydrogen or halo; R.sup.4 and R.sup.5 each independently are hydrogen, C.sub.1-4 alkyl or haloC.sub.1-4 alkyl; and the group NR.sup.4 R.sup.5 may also be azido, Alk is C.sub.2-4 alkanediyl; pharmaceutical compositions containing said compounds of formula (I) as active ingredient; use of said compounds as a medicine; process of preparing said compounds; compounds of formula (I) containing a radioactive isotope; process of marking 5HT.sub.2 -receptor sites; and process for imaging an organ are disclosed.

REFERENCES:
Appel et al. "Autoradiographic characterization of 1-(2,5-dimethoxy-4-iodo(125)phenyl)-2-aminopropane binding to 5HT2 and 5HTic receptors in rat brain." J. Pharm. Exp. Ther., 1990.

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