Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing compound containing saccharide radical
Patent
1995-06-06
1998-09-15
Zitomer, Stephanie W.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing compound containing saccharide radical
435 71, 435 72, 435 721, 435 691, 4351723, 435325, G01N 3353, C12P 2102, C12N 1563, C12N 1509
Patent
active
058076891
ABSTRACT:
In accordance with the present invention, there are provided nucleic acids encoding human metabotropic glutamate receptor subtypes and the proteins encoded thereby. In a particular embodiment, the invention nucleic acids encode mGluR1, mGluR2, mGluR3 and mGluR5 subtypes of human metabotropic glutamate receptors. In addition to being useful for the production of metabotropic glutamate receptor subtypes, these nucleic acids are also useful as probes, thus enabling those skilled in the art, without undue experimentation, to identify and isolate related human receptor subunits. In addition to disclosing novel metabotropic glutamate receptor subtypes, the present invention also comprises methods for using such receptor subtypes to identify and characterize compounds which affect the function of such receptors, e.g., agonists, antagonists, and modulators of glutamate receptor function.
REFERENCES:
patent: 5385831 (1995-01-01), Mulvhill et al.
patent: 5500420 (1996-03-01), Maiese
Abe et al., J. Biol. Chem. 262(19):13361-13368 (Feb. 5, 1992).
Masu et al., Nature 349:760-765 (Feb. 28, 1991).
Daggett Lorrie
Ellis Steven B.
Hess Stephen D.
Johnson Edwin C.
Liaw Chen
Raymer Gregory P.
Reiter Stephen E.
SIBIA Neurosciences Inc.
Zitomer Stephanie W.
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