Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Reexamination Certificate
2002-12-04
2008-12-16
Allen, Marianne P (Department: 1647)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
C530S399000
Reexamination Certificate
active
07465704
ABSTRACT:
The invention relates to the use of Epidermal Growth Factor (EGF) in a preferably-injectable pharmaceutical composition which is administered by means of infiltration into and around chronic cutaneous ischaemic lesions in order to prevent diabetic foot amputation. Said composition can be administered to recently-created surgical surfaces damaged by the effect of acute reperfusion with oxygenated blood following prolonged ischaemia, thereby preventing further surgical procedures and favouring the preservation of the extremity. The aforementioned composition can be used to improve (i) the cell microenvironment, thereby increasing the reparative and defensive capacity and viability of the is tissues and (ii) the cicatrisation of cutaneous ischaemic lesions, thereby stimulating cell proliferation. The invention is suitable for use in human, veterinary and experimental medicine, specifically in vascular angiology and surgery, dermatology, burn treatment and reconstructive surgery and geriatric medicine. Said composition can be used for recalcitrant ulcers which are associated with lesions in the macro and/or microvasculature, patients with inadequate lymphatic and/or venous return and ulcers or other lesions which are difficult to cicatrise and/or heal.
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Brown G. L. et al., “Stimulation of Healing of Chronic Wounds by Epidermal Growth Factor”,Plastic and Reconstructive Surgery(1991), 88(2):189-194.
Brown G. L. et al., “Enhancement of Epidermal Regeneration by Biosynthetic Epidermal Growth Factor”,The Journal of Experimental Medicine(1986), 163(5):1319-1324.
Hogge J. et al., “The Potential Benefits of Advanced Therapeutic Modalities in the Treatment of Diabetic Foot Wounds”,J. American Podiatric Med. Assoc.(2000), 90(2):57-65.
Zhu Xier et al., “Studies on Enhancing the Repair of Gangrenous Skin Diabetic Foot by Epidermal Growth Factor”,5thChina-Japan Symposium on Diabetes Mellitus(1997), 1141:241-243.
English Translation of Zhu et al., “Clinical Studies on Enhancing the Repair of Gangrenous Skin of Diabetic Foot by Epidermal Growth Factor,”Natl. Med. J. China.,1996, 76:862.
Berlanga Acosta Jorge
Canan-Haden Frías Leonardo
Chacón Corvea Larissa
Fernández Montequin José I
Franco Pérez Neobalis
Allen Marianne P
Centro de Ingeniera Genetica y Biotecnologia
Hoffman & Baron LLP
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