Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant...
Patent
1991-12-27
1993-06-08
Stoll, Robert L.
Drug, bio-affecting and body treating compositions
Radionuclide or intended radionuclide containing; adjuvant...
5303915, A61K 4900, A61K 4902
Patent
active
052177041
ABSTRACT:
The present invention provides a metal ion scavenging procedure and antibody compositions for radioimmunoscintigraphy and cytotoxic radioimmunotherapy having chelator concentrations of greater than about 10.sup.-4 M which are optimized with respect to their metal binding capacity such that highly efficient labelling of the antibody is achieved in a simple one step procedure using readily available sources of radiometal ions.
REFERENCES:
patent: 4472509 (1984-09-01), Gansow et al.
Patt, Y. Z., et al., "Improved Tumor Localization With Increasing Dose of Indium-III-Labeled Anti-Carcinoembryonic Antigen Monoclonal Antibody ZCE-025 in Metastatic Colorectal Cancer", J. Clin. Oncology, 6(8):1220 (1988).
Abdel-Nabi, H. H., et al., "Colorectal Carcinoma: Detection with Indium-III-Anticarcinoembroyonic-Antigen Monoclonal Antibody ZCE-025", Radiology, 617 (Sep., 1987).
Meares, et al., Conjugation of Antibodies with Bifunctional Chelating Agents . . . , Analytical Biochemistry, 142, 68-78, (1984).
Paik et al., Optimization of the DTPA Mixed-Anhydride Reaction with Antibodies at Low Concentration, Journal of Nuclear Medicine, 24, 932-936, 1983.
Johnson David K.
Rogers Patrick E.
Abbott Laboratories
Curry Daniel R.
Pope Lawrence S.
Sayala C.
Stoll Robert L.
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