Methods and compounds for producing dipeptidyl peptidase IV...

Details Methods and compounds for producing dipeptidyl peptidase IV... Methods and compounds for producing dipeptidyl peptidase IV...

2008-09-02

2008-09-02

Anderson, Rebecca L (Department: 1626)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

C560S174000, C560S189000

Reexamination Certificate

active

10716012

ABSTRACT:
Methods and compounds for production of cyclopropyl-fused pyrrolidine-based inhibitors of dipeptidyl peptidase IV are provided.

REFERENCES:
patent: 3325478 (1967-06-01), Hermann et al.
patent: 6068991 (2000-05-01), Liu et al.
patent: 6395767 (2002-05-01), Robl et al.
patent: 0 808 824 (1997-11-01), None
patent: WO 00/04179 (2000-01-01), None
patent: WO2004/037181 (2004-05-01), None
patent: WO2005/012249 (2005-02-01), None
patent: WO2005/049022 (2005-06-01), None
Hanessian, S. et al., “Probing the Importance of Spacial and Conformational Domains in Captopril Analogs for Angiotensin Converting Enzyme Activity”, Bioorganic & Medicinal Chemistry Letters, vol. 8, pp. 2123-2128 (1998).
Hanson, R.L. et al., Synthesis of allysine ethylene acetal using phenylalanine dehydrogenase fromThermoactinomyces intermedius, Enzyme and Microbial Technology, vol. 26, pp. 348-358 (2000).
Imashiro, R. et al., “Asymmetric synthesis of methyl (2R,3S)-3-(4-methoxyphenyl) glycidate, a key intermediate of diltiazem, via Mukaiyama aldol reaction”, Tetrahedron Letters, vol. 42, pp. 1313-1315 (2001).
Reetz, M.T. et al., “General Synthesis of Potentially Antiviral α-Adamantyl Carbonyl Compounds”, Angew. Chem. Int. Ed. Engl., vol. 18, No. 1, p. 72 (1979).
Sagnard, I. et al., “Enantioselective Synthesis of Cyclopropane α-Amino Acids: Synthesis of N-Boc-cis-(2S,3R,4S)-3,4-Methanoproline and N-Boc-(2S,3R,4S)-3,4-Methanoglutamic Acid”, Tetrahedron Letters, vol. 36, No. 18, pp. 3148-3152 (1995).
Takada, H. et al., “Thermostable Phenylalanine Dehydrogenase ofThermoactinomyces intermedius: Cloning, Expression, and Sequencing of Its Gene”, J. Biochem., vol. 109, pp. 371-376 (1991).
Tverezovsky, V.V. et al., “Synthesis of (2S,3R, 4S)-3,4-Methanoproline and Analogues by Cyclopropylidene Insertion”, Tetrahedron, vol. 53, No. 43, pp. 14773-14792 (1997).
U.S. Appl. No. 11/091,183, filed Mar. 28, 2005, Sharma et al.
U.S. Appl. No. 11/104,015, filed Apr. 12, 2005, Politino et al.
U.S. Appl. No. 11/119,552, filed May 2, 2005, Patel et al.
U.S. Appl. No. 11/135,217, filed May 23, 2005, Sharma.
Bott, et al., “Synthesis of alpha.-chloro-1-adamantylacetic acids and.alpha.-chloro-2-norbornaneacetic acid by means of trichloroethylene”, Chemical Abstracts, Accession No. 1968:21595, (1967).
Clariana, J. et al, “Preparation of (R)-(1-adamantyl)glycine and (R)-2-(1-adamantyl)-2-aminoethanol: a combination of cobalt-mediated β-ketoester alkylation and enzyme-based aminoalcohol resolution”, Tetrahedron: Asymmetry 11, 2000, pp. 4549-4557.
Janku, J. et al., “Adamantane and its derivatives. XXXIV. Preparation of 1-adamantylchloroacetic acid”, Chemical Abstracts, Accession No. 1976:105072, (1973).
Kottirsch, G., et al., “Fibrinogen receptor antagonists containing a gamma-lactam Gly-Asp isosters”, Database Accession No. 120:299271, Bioorganic & Medicinal Chemistry Letters, 3(8), 1993.
Kranyushkin, M. et al., “Synthesis and properties of .alpha.-c-nitrohydrazones. 3. Interaction of salts of asymmetric hydrazines with compounds containing trinitromethyl groups and with polynitromethanes”, Database Accession No. 1980:494874, (1980).
Krasutskii, P.A. et al., “Synthesis and chemical characteristics of .alpha.-halo(1-adamantyl)acetyl halides”, Chemical Abstracts, Accession No. 1985:422196, (1984).
Krasutskii, P.A. et al., “alpha.-Amino acids of the adamantine series, II. Synthesis and isomer separation of 1,3-adamantane diglycine. Stereo-chemistry of amination of .alpha.-bromo acids of the adamantane series”, Accession No. 1986: 625851, (1985).
Krasutskii, P.A. et al., “Amino acids of the adamantane series. I. Synthesis and antiviral activity of adamantane .alpha.-amino acids and their derivatives”, Accession No. 1986:130230, (1985).
Krasutskii, P.A. et al., “.alpha.-Amino acids of the adamantane series. I. Synthesis and resolution of -adamantylglycine and .beta.-(1-adamantyl)alanine”, Accession No. 1986: 406210 (1985).
Ohno, M. et al., “Ethyl 3-(1-Adamantyl)-2-diazo-3-oxopropanoate: Synthetic Use of the Preparation of Some Adamantane Derivatives”, Synthesis (8), pp. 793-796, 1993.
Stetter, H. et al. “Compounds with urotropine structure. XVI. The chemistry of 1-adamantyl derivatives”, Chemische Berichte, 93, 226-230, (1960).
Yurchenko, A.G. et al, “.alpha. -Amino-1-adamantaneacetic acid”, Accession No. 1982: 472778 (Mar. 1982).

Affiliated with

Also associated with

Rating

Methods and compounds for producing dipeptidyl peptidase IV... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Methods and compounds for producing dipeptidyl peptidase IV..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods and compounds for producing dipeptidyl peptidase IV... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3916643