Methods and compositions using stearoyl-CoA desaturase to...

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Reexamination Certificate

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C424S768000, C435S007100, C435S007710, C435S025000, C435S026000, C435S183000, C435S189000, C514S866000, C514S909000

Reexamination Certificate

active

07816075

ABSTRACT:
The use of screening assays based on the role of human stearoyl-CoA desaturase-1 (“hSCD1”) in human diseases, disorders or conditions relating to serum levels of triglyceride, VLDL, HDL, LDL, total cholesterol, or production of secretions from mucous membranes, monounsaturated fatty acids, wax esters, and the like, is disclosed. Also disclosed are conventions useful in the prevention and/or treatment of such diseases.

REFERENCES:
patent: 4696916 (1987-09-01), Yabushita et al.
patent: 5336496 (1994-08-01), Akimoto et al.
patent: 5443974 (1995-08-01), Hitz et al.
patent: 5554646 (1996-09-01), Cook et al.
patent: 5702902 (1997-12-01), Tartaglia
patent: 6162455 (2000-12-01), Cleale
patent: 6288114 (2001-09-01), Bauman et al.
patent: 2003/0064950 (2003-04-01), Ntambi et al.
patent: 0238198 (1987-02-01), None
patent: 9108234.6 (1990-08-01), None
patent: WO 96/05861 (1996-02-01), None
patent: WO 99/63979 (1999-12-01), None
patent: WO 00/09754 (2000-02-01), None
patent: WO 01/62954 (2001-08-01), None
Sessler et al.1998. Polyunsaturated Fatty Acid Regulation of Gene Expression. Journal of Nutrition, vol. 128, pp. 923-926.
Jean-Charles Martin et al. 2000. Cyclic Fatty Acid Monomers From Heated Oil Modify The Activities Of Lipid Synthesizing And Oxidizing Enzymes In Rat Liver. The Journal of Nutrition, vol. 130, pp. 1524-1530.
Ward et al (1998. Allergic Responses to the BiopesticideMetarhizium anisopliaein Balb/c Mice. Toxicological Sciences, vol. 45, pp. 195-203.
Clarke et al., Prog. Lipid Res., 32, 139-149 (1993).
Kim et al., J. Lipid Res., 41, 1310-1316 (2000).
Skrede et al., Biochim. Biophys. Acta, 1344, 115-131 (1997).
Li et al., Int.J. Cancer, 57, 348-352 (1994).
Miyazaki et al., J. Biol. Chem., 275, 30132-30138 (2000).
Paisley et al., J. Nutr., 126, 2730-2737 (1996).
Waters et al., J. Biol. Chem., 269, 27773-27777 (1994).
Choi, et al., “The trans-10, cis-12 Isomer of Conjugated Linoleic Acid Downregulates Stearoyl-CoA Desaturase 1 Gene Expression in 3T3-L1 Adipocytes,” J. Nutrition, vol. 130, pp. 1920-1924 (2000).
Zoeller, et al., “The importance of the stearoyl-CoA desaturase system in octadecenoate metabolism in the Morris hepatona7288C,” Biochim. Biophys. Acta, vol. 845, pp. 380-388 (1985).
Bretillon, et al., “Effects of Conjugated Linoleic Acid Isomers on the Hepatic Microsomal Desaturation Activities in Vitro,” Lipids, vol. 24, No. 9, pp. 965-969 (1999).
Hovik, et al., “Thia fatty acids as substrates and inhibitors of stearoyl-CoA desaturase,” Biochim. Biophys. Acta, vol. 845, pp. 251-256 (1997).
Khoo, et al., “Manipulation of body fat composition with sterculic acid can inhibit mammary carcinomas in vivo,” British J. Cancer, vol. 63, pp. 97-101 (1991).
Cao, et al., “Inhibition of fatty acidΔ6- andΔ5-desaturation by cyclopropene fatty acids in rat liver microsomes,” Biochim. Biophys. Acta, vol. 1210, pp. 27-34 (1993).
Park, et al., “Inhibition of hepatic stearoyl-CoA desaturase activity by trans-10, cis-12 conjugated linoleic acid and its derivatives,” Biochim. Biophys. Acta, vol. 1486, pp. 285-292 (2000).
de Antueno, et al., “Relationship Between Mouse liverΔ9 Desaturase Activity,” Lipids, vol. 28, No. 4 (1993).
Legrand, et al., “InhibitingΔ9-Desaturase Activity Impairs Triacylglycerol Secretion in Cultured Chicken Hepatocytes” J. Nutrition, vol. 127, pp. 249-256 (1997).
Grinari, et al., “Conjugated Linoleic Acid is Synthesized Endogenously in Lactating Dairy Cows byΔ9-Desaturase,” J. Nutrition, vol. 130, pp. 2285-2291, (2000).
Jeffcoat, et al., “Studies on the Inhibition of the Desaturases by Cyclopropenoid Fatty Acids,” Lipids, vol. 12, pp. 480-485 (1977).
Jeffcoat, et al., “Interrelationship between the Dietary Regulation of Fatty Acid Synthesis and the Fatty Acyl-CoA Desaturases,” Lipids, vol. 12, pp. 469-474 (1977).
Kaestner, et al., “Differentiation-induced Gene Expression in 3T3-L1 Preadipocytes,” Journal of Biological Chemistry, vol. 264, No. 25, pp. 14755-14761 (1991).
Ntambi, “Scd1 is expressed in sebaceous glands and is disrupted in the asebia mouse,” Nature Genetics, vol. 23, p. 268 (1999).
Ntambi, “Regulation of stearoyl-CoA desaturase by polyunsaturated fatty acids and cholesterol,” Journal of Lipid Research, vol. 40, pp. 1549-1558 (1999).
Legrand, et al., “HepaticΔ9 desaturation and plasma VLDL level in genetically lean and fat chickens,” International Journal of Obesity, vol. 16, pp. 289-294 (1992).
Legrand, et al., “Stearoyl-CoA Desaturase Activity in Primary Culture of Chicken Hepatocytes. Influence of Insulin, Glucocorticoid, Fatty Acids and Cordycepin,” Intl. J. Biochem, vol. 26, No. 6, pp. 777-785 (1994).
Lefevre, et al., “Hormonal Regulation of Stearoy1 Coenzyme-A Desaturase 1 Activity and Gene Expression in Primary Cultures of Chicken Hepatocytes,” Archives of Biochemistry and Biophysics, vol. 368, No. 2, pp. 329-337 (Aug. 15, 1999).
Legrand, et al., Effect of Insulin on Triacylglycerol Synthesis and Secretion by Chicken Hepatocyts in Primary Culture, Int'l. J. Biochem Cell Bio., vol. 28, No. 4, pp. 431-440 (1996).
Li, et al., “Partial Characterization of a cDNA for Human Stearoyl-CoA Desaturase and Changes in its mRNA Expression in Some Normal and Malignant Tissues,” Int'l J. Cancer, vol. 57, pp. 348-352 (1994).
Waters et al., “Localization of a Negative Thyroid Hormone-Response Region in Hepatic Stearoyl-CoA Desaturase Gene I”, Biochem. Biophys. Res. Comm., vol. 233, pp. 838-843, (1997).
Zhang et al., “Human Stearoyl-CoA Desaturase: Alternative Transcripts enerated from a Single Gene by Usage of Tandem Polyadenylation Sites”, Biochem. J., vol. 340, pp. 255-264 (1999).
Database Biosis Online. Waters & Ntambi: “Polyunsaturated Fatty Acids Inhibit Hepatic Stearoyl-CoA Desaturase-1 Gene in Diabetic Mice”, vol. 31, No. Suppl., pp. S33-S36 (1996), Accession No. PREV199698795704.
Kurebayashi S. et al., “Thiazolidinediones Downregulate Stearoyl-CoA Desaturase 1 Gene Expression in 3T3-L1 Adipocytes”, Diabetes, vol. 46, pp. 2115-2118, Dec. 1997.
Singh & Ntambi, “Nuclear Factor 1 is Essential Fir the Expression of Stearoyl-CoA Desaturase 1 Gene During Preadipocyte Differentiation”, Biochim. Biophys. Acta., vol. 1398, 1998, pp. 148-156.
Sessler et al., “Regulation of Stearoyl-CoA Desaturase 1 mRNA Stability by Polyunsaturated Fatty Acids in 3T3-L1 Adipocytes”, J. Biol. Chem., vol. 271, No. 47, pp. 29854-29858 (Nov. 22, 1996.).
Ntambi, J.M., “Regulation of Stearoyl-CoA Desaturase by Polyunsaturated Fatty Acids and Cholesterol”, J. Lipid Res. vol. 40, pp. 1549-1558 (1999).
Park et al., “Lipid Level and Type Alter Stearoyl CoA Desaturase mRNA Abundance Differently in Mice with Distinct Susceptibilities to Diet-Influenced Diseases”, J. Nutrition, vol. 127, pp. 566-573 (1997).
Agrawal et al., Molecular Med. Today, vol. 6, pp. 72-81 (2000).
Branch, A., Trends in Biochem. Sci. (TIBS), vol. 23, pp. 45-50 (1998).
Cook, S.T., Antisense Res. and Applica., Chapter 2, pp. 51-101, S. Crooke, S. Ed. (Springer-Verlag 1998).
Crooke, S.T., Antisense Res. and Applica., Chapter 1, pp. 1-50, S. Crooke, S. Ed. (Springer-Verlag 1998).
Derossi et al., J. Biol. Chem., vol. 269, pp. 10,444-10,450 (1994).
Elliott et al., Cell, vol. 88, pp. 223-233 (1997).
Hamilton, J., J. Lipid Res., vol. 39, pp. 467-481 (1998).
Kinsella et al., Am. J. Clin. Nutr., vol. 52, pp. 1-28 (1990).
Legrand et al., J. Nutrition, vol. 127 (No. 2, Feb. 1997), pp. 249-256.
Martin et al., J. Nutrition, vol. 130, pp. 1524-1530 (2000).
Moreton et al., Applied Microbiol. Biotech., vol. 22, pp. 42-45 (1984).
Pan et al., J. Nutrition, vol. 124 (No. 9), pp. 1555-1565 (1994).
Pooga, M., FASEB J., vol. 12, pp. 67-77 (1998).
Jiang et al., J. Clin. Invest., vol. 115, pp. 1030-1038 (2005).
Lee et a

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