Drug – bio-affecting and body treating compositions – Lymphokine – Interferon
Patent
1999-11-22
2000-09-26
Guzo, David
Drug, bio-affecting and body treating compositions
Lymphokine
Interferon
530351, 514 2, 435 701, 424 43, 424 46, 424489, 424491, A61K 3821, C07K 136
Patent
active
061239364
ABSTRACT:
According to the present invention, methods and compositions are provided for spray-dried, interferon-based dry powder compositions, particularly interferon-beta. The compositions are useful for treating conditions in humans that are responsive to treatment with interferons. In particular, the methods of the present invention rely on spray drying to produce stable, high-potency dry powder formulations of interferons, including but not limited to IFN-beta. Surprisingly, it has been found that IFN can be prepared in high potency, dry powder formulations by spray drying. Such dry powder formulations find particular utility in the pulmonary delivery of IFN.
REFERENCES:
patent: 5049389 (1991-09-01), Radhakrishnan
Foster Linda C.
Kimura Shigenobu
Platz Robert M.
Satoh Yu-ichiro
Burst Stephen L.
Cagan Felissa H.
Evans Susan T.
Guzo David
Inhale Therapeutics Systems, Inc.
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