Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1997-11-06
2000-02-15
MacMillan, Keith D.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
536 234, 536 231, 5361187, 435 6, 530350, C07H 2100
Patent
active
060254858
ABSTRACT:
Methods and compositions for peptides or protein fragments displayed on scaffolds and libraries of sequences encoding peptides or protein fragments displayed on scaffolds that permit the properties of the library to be easily and quantitatively monitored are disclosed. The scaffold is a protein that is capable of emitting light. Thus, analysis of the expression of individual members of the library when they are expressed in cells may be carried out using instruments that can analyze the emitted light, such as flow sorter (FACS), a spectrophotometer, a microtitre plate reader, a CCD, a fluorescence microscope, or other similar device. This permits screening of the expression library in host cells on a cell-by-cell basis, and enrichment of the library for sequences that have predetermined characteristics.
REFERENCES:
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Clontech Catalog 97/98 pp. 111-118.
Clontech Catalog 98/99 pp. 151-162.
Martin, Franck, et al., "The affinity-selection of a minibody polypeptide inhibitor of human interleukin-6," The EMBO Journal, 13(22), pp. 5303-5309, 1594.
Pessi, A., et al. "A designed metal-binding protein with a novel fold," Nature, 362 367-369, Mar. 25, 1993.
Abedi Majid
Kamb Carl Alexander
Arcaris, Inc.
MacMillan Keith D.
Shuster Michael J.
Wessendorf T.
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