Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2004-08-16
2009-02-03
Horlick, Kenneth R. (Department: 1637)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
Reexamination Certificate
active
07485420
ABSTRACT:
This application describes methods and compositions for detecting and treating vimentin-associated neoplasia. Differential methylation of the vimentin nucleotide sequences has been observed in vimentin-associated neoplasia such as colon neoplasia.
REFERENCES:
patent: 5786146 (1998-07-01), Herman et al.
patent: 6017704 (2000-01-01), Herman et al.
patent: 6200756 (2001-03-01), Herman et al.
patent: 6265171 (2001-07-01), Herman et al.
patent: 2003/0148327 (2003-08-01), Olek et al.
patent: 2004/0048279 (2004-03-01), Olek et al.
patent: WO 0177373 (2001-10-01), None
patent: WO 0177376 (2001-10-01), None
patent: WO 02/18632 (2002-03-01), None
Langa et al. (J Cell Sci. Oct. 2000;113 Pt 19:3463-72).
Baylin and Bestor (Cancer Cell. May 2002;1(4):299-305).
Domagala et al. Am J Pathol. Jan. 1990;136(1):219-27.
Evans Bioessays. Jan. 1998;20(1):79-86. Review.
Printout: Lucentini et al (The Scientist (2004) vol. 18).
Wacholder et al (J. Natl. Cancer Institute (2004) 96(6):434-442).
Chen et al. (Natl Cancer Inst. Aug. 3, 2005;97(15):1124-32).
Lagendijk et al (Clin Pathol. Apr. 1999;52(4):283-90).
WIPO http://www.wipo.int/pctdb/en/search-adv.jsp.
USPTO Seq ID No. 2 search Result 11.
Domagala et al (Am J Pathol. Jan. 1990;136(1):219-27).
Lange et al. (J Cell Sci. Oct. 2000;113 Pt 19:3463-72).
Baylin and Bestor (Cancer Cell. May 2002;1(4):299-305.
Lucentini et al (The Scientist (2004) vol. 18).
Herman et al. (“Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands” Proc Natl Acad Sci U S A. Sep. 3, 1996;93(18):9821-6).
Lucentini et al. (The Scientist (2004) vol. 18).
Wacholder et al. (J. Natl. Cancer Institute (2004) 96(6):434-442.
Domagala, W. et al., “Vimentin Is Preferentially Expressed in Human Breast Carcinomas With Low Estrogen Receptor and High Ki-67 Growth Fraction” American Journal of Pathology, 136(1); pp. 219-227, (1990).
Eden, Sharon et al., “Role of DNA methylation in the regulation of tanscription”, Current Opinion in Genetics and Development, 4(2), pp. 255-259 (1994).
Izmailova, E. S. et al., “A GC-box is required for expression of the human vimentin gene”, Gene, 235(1-2) p. 69-75 (1999).
Langa, Francina, et al., “Teratocarcinomas induced by embryonic stem (ES) cells lacking vimentin: An approach to study the role of vimentin in tumorigenesis”, Journal of Cell Science, 113(19) pp. 3463-3472 (2000).
Petko, Zsolt, et al., “Aberrantly methylated CDKN2A, MGMT and hMLH1 are biomarkers for colon adenomas and color adenocarcinomas”, Proceedings of the American Association for Cancer Research Annual Meeting, 44, pp. 698 (2003).
Attwood, J.T. et al. DNA methylation and the regulation of gene transcription. Cell Mol. Life Sci. 59, 241-257 (2002).
Baylin, S.B. et al. Alterations in DNA Methylation: A Fundamental Aspect of Neoplasia. Adv. Cancer Res., 72, 141-196 (1998).
Baylin, S. et al. Altered methylation patterns in cancer cell genomes: Cause or consequence? Cancer Cell 1, 299-305 (2002).
Costello, J.F. et al. Aberrant CpG-island methylation has non-random and tumour-type-specific patterns. Nat. Genet. 25, 132-138 (2000).
Evans, R.M., et al. Vimentin : the conundrum of the intermediate filament gene family. BioEssays 20, 79-86 (1998).
Gonzalez-Zulueta, M. et al. Methylation of the 5′ CpG Island of thep16/CDKN2Tumor Suppressor Gene in Normal and Transformed Human Tissues Correlates with Gene Silencing. Cancer Res. 55, 4531-4535 (1995).
Gonzalgo, M.L. et al. Rapid quantitation of methylation differences at specific sites using methylation-sensitive single nucleotide primer extension (Ms-SNuPE). Nucleic Acids Res. 25, 2529-2531 (1997).
Grady, W.M. et al. Detection of Aberrantly MethylatedhMLH1Promoter DNA in the Serum of Patients with Microsatellite Unstable Colon Cancer. Cancer Res. 61, 900-902 (2001).
Herman, J.G. et al. Inactivation of theCDKN2/p16/MTS1Gene is Frequently Associated with Aberrant DNA Methylation in all Common Human Cancers. Cancer Res. 55, 4525-4530 (1995).
Herman, J.G. et al. Methylation-specific PCR: A novel PCR assay for methylation status of CpG islands. PNAS 93, 9821-9826 (1996).
Hibi, K. et al. Molecular Detection of Genetic Alterations in the Serum of Colorectal Cancer Patients. Cancer Res. 58, 1405-1407 (1998).
Jeronimo, C. et al. Quantitation of GSTP1 Methylation in Non-neoplastic Prostatic Tissue and Organ-Confined Prostate Adenocarcinoma. J. Natl. Cancer Inst. 93, 1747-1752 (2001).
Jones, P.A. et al. The DNA methylation paradox. Trends Genet. 15, 34-37 (1999).
Kane, M.F. et al. Methylation of thehMLH1Promoter Correlates with Lack of Expression of hMLH1 in Sporadic Colon Tumors and Mismatch Repair-defective Human Tumor Cell Lines. Cancer Res. 57, 808-811 (1997).
Li, H. et al. SLC5A8, a sodium transporter, is a tumor suppressor gene silenced by methylation in human color aberrant crypt foci and cancers. PNAS 100(14), 8412-8417 (2003).
Markowitz, S. et al. Inactivation of the Type II TGF-$\beta$ Receptor in Colon Cancer Cells with Microsatellite Instability. Science 268, 1336-1338 (1995).
Moinova, H.R. et al. HLTF gene silencing in human colon cancer. PNAS 99, 4562-4567 (2002).
Paramio, J.M. et al. Beyond structure: do intermediate filaments modulate cell signalling? BioEssays 24, 836-844 (2001).
Usadel, H. et al. Quantitative Adenomatous Polyposis Coli Promoter Methylation Analysis in Tumor Tissue, Serum, and Plasma DNA of Patients with Lung Cancer. Cancer Res. 62, 371-375 (2002).
Veigl, M.L. et al. Biallelic inactivation ofhMLH1by epigenetic gene silencing, a novel mechanism causing human MSI cancers. PNAS 95, 8698-8702 (1998).
Willson, J.K.V. et al. Cell Culture of Human Colon Adenomas and Carcinomas. Cancer Res. 47, 2704-2713 (1987).
Xiong, Z. et al. COBRA: a sensitive and quantitative DNA methylation assay. Nucleic Acids Res. 25, 2532-2534 (1997).
Babic Christopher M.
Case Western Reserve university
Horlick Kenneth R.
Ropes & Gray LLP
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