Method to reduce introacular pressure without causing miosis

Details Method to reduce introacular pressure without causing miosis Method to reduce introacular pressure without causing miosis

1990-10-01

1992-10-06

Waddell, Frederick E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514255, 514315, 514397, 514 63, A61K 31445, A61K 31415, A61K 31495

Patent

active

051532050

ABSTRACT:
Topical administration of a cholinomimetic agent, such as pilocarpine, in combination with a cholinergic M.sub.3 receptor antagonist, such as 4-diphenyl-acetoxy-N-methylpiperidine, to the eye of a mammal reduces intraocular pressure without the concommitant miotic effect that normally occurs with administration of a cholinomimetic agent along.

REFERENCES:
Invest Ophthamol Vis Sci., Jul. (1990), 31 pp. 1332-1338, Liu et al.
The Merck Index, Tenth Edition, 1983.
Ann. Rev. Pharmacol. and Toxicol., George, R., Okun, R., Cho, A., eds. 26, pp. 401-426 (1986).
Glaucoma: Applied Pharmacol. in Med. Treatment, Drance, S., Neufeld, A., eds., pp. 357-393 (1984).
Doods, et al., J. Pharmacol. and Experim. Therapeutics, 242 No. 1, pp. 257-262 (1987).
Zimmerman, et al., Opthalmology, 89 No. 1, pp. 76-80 Jan. 1982.

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