Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Virus or component thereof
Patent
1997-09-15
1999-04-06
Saunders, David
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Virus or component thereof
4242341, 4242581, 4242691, 435 695, 435 705, 435349, 435390, A61K 39002, A61K 3902, A61K 3912, C12P 2100
Patent
active
058914439
ABSTRACT:
Immortal avian T lymphocyte cell lines which produce and secrete immune lymphokines are disclosed. These cell lines may be produced from T cells recovered from fowl which have been hyperimmunized in vivo. The activated T cells are first exposed in vitro to a mitogen effective for secondary stimulation thereof, and then virally transformed to produce an immortal cell line. When cultured in vitro, the cell lines produce and secrete immune lymphokines which may be administered to fowl to increase their resistance to infections.
REFERENCES:
patent: 5691200 (1997-11-01), Kogut et al.
Tellez, G.I., Kogut, M.H., Hargis, B.M., "Immunoprophylaxis of Salmonella enteritidisInfecton by Lymphokines in Leghorn Chicks." Avian Diseases, 1993, vol. 37, pp. 1062-1070.
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Kogut, M.H., McGruder, E.D., Hargis, B.M., Corrier, D.E., DeLoach, J.R. "In Vivo Activation of Heterophil Function in Chickens Following Injection with Salmonella Enteritidis-Immune Lymphokines," Journal of Leukocyte Biology, Jan. 1995, vol. 57, pp. 56-62.
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Marmor, MD et al. J. Exp. Med. 177:647-656, Mar. 1993.
DeLoach John R.
Hargis Billy M.
Kogut Michael H.
Moyes Rita B.
Stanker Larry H.
Deck Randall E.
Fado John D.
Saunders David
Silverstein M. Howard
The Texas & M University System College
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