Method to induce cytotoxic T Lymphocytes specific for a broad ar

Details Method to induce cytotoxic T Lymphocytes specific for a broad ar Method to induce cytotoxic T Lymphocytes specific for a broad ar

1991-09-18

1998-10-13

Stucker, Jeffrey

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Amino acid sequence disclosed in whole or in part; or...

4242081, 530326, 530327, A61K 3921

Patent

active

058208658

ABSTRACT:
The instant invention describes the synthesis of short peptides, corresponding to the amino acid residues of the V3 loop of the gpl6O envelope glycoprotein of HIV-1 numbered 315 to 329 by Ratner (Ratner, L. et al., Nature 313, 277 (1985)) in the strain IIIB, wherein the residue corresponding to number 325 in HIV-1 IIIB is substituted by the homologous residue from another clinical isolate or strain. The invention further describes the use of said peptides in pharmaceutical compositions and an immunization protocol which elicits cytotoxic T cells reactive to a broad range of isolates of HIV-1.

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