Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Cyclopentanohydrophenanthrene ring system doai
Patent
1991-03-29
1993-10-12
Waddell, Frederick E.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Cyclopentanohydrophenanthrene ring system doai
552528, 552529, A61K 3156
Patent
active
052525643
ABSTRACT:
A method for decreasing the adrenal secretion of glucocorticoids, especially cortisol, in male livestock without substantially suppressing the animal's immune system by oral or other administration of effective doses of melengesterol acetate (MGA) or derivatives thereof. Ideally, the MGA may be used in admixture with the subject animal feed, although it is understood that the compound may be administered separately.
REFERENCES:
C. A. Nugent et al., "Suppression of Cortisol by a Progestational Steroid, Melengestrol," Clinical Pharmacology and Therapeutics 18(3):338-344 (1975).
W. R. Robertson et al., "The Effect of Some Antiprostatic Steroids Upon Cortisol Production by Guinea-Pig Adrenal Cells Stimulated by ACTH," Biochem. Pharmacol. 38(21):3669-3671 (1989).
. . , "Shipping Fever: Drive It Out!," Agricultural Research, pp. 12-13 (Mar. 1990).
James A. Roth, "Immunosuppression and Immunomodulation in Bovine Respiratory Disease," In Bovine Respiratory Disease, A Symposium, ed. Raymond W. Loan, pp. 143-192, Texas A&M University Press.
Richard L. Elton et al., "Biological Activities of Some 6-Methylated Progesterones," P.S.E.B.M., 103: 175-177 (1960).
R. D. Randel et al., "Effect of Melengestrol Acetate on Plasma Progesterone, Luteinizing Hormone and Total Corticoids in Dairy Heifers," J. Animal Science 35(2): 389-397 (1972).
Gordon W. Duncan et al., "Biologic Effects of Melengestrol Acetate," Fertility & Sterility, 15(4): 419-432 (1964).
G. R. McKinney et al., "The Adrenal Responses to Stress of Rats Treated with Certain Progestagens," Abstract, Fourth Annual Meeting, Toxicol. Appl. Pharm., 7: 491 (1965).
Deborah J. Middleton et al., "Suppression of Cortisol Responses to Exogenous Adrenocorticotrophic Hormone, and the Occurrence of Side Effects Attributable to Glucorticoid Excess, in Cats During Therapy with Megestrol Acetate and Prednisolone," Can. J. Vet. Res., 51: 60-65 (1987).
R. C. Upadhyay et al., "Studies on the Effects of Liv. 52 and Melengesterol Acetate (MGA) on Body Weights and Certain Blood Constituents of Poultry," Chem. Abstr. 104: 50259c, pp. 463-464 (1986).
M. N. Sillence et al., "Age- and Sex-Dependent Stimulation of Growth Rate in Rats by the Adrenal Inhibitor Trilostane", J. Endocr. 113: 479-484 (1987).
M. N. Sillence et al., "Effects of Trenbolone Acetate and Testosterone on Growth and on Plasma Concentrations of Corticosterone and ACTH in Rats," J. Endocr., 126: 461-466 (1990).
M. N. Sillence et al., "Effects of Metyrapone and Etomidate on Adrenal Function and Growth Rate in Female Rats," J. Endocr., 113: 473-478 (1987).
R. B. Buckland et al., "Effect of Feeding Chlorpromazine, Metyrapone and Pargyline to Chicks on Plasma Corticoid Levels and the Effect of Stress on Their Relationship to Body Weight," Poult. Sci., 52: 1215-1217 (1973).
A. R. Ezzat, "Enhancement of the Adrenocortical Response to Metyrapone by L-Dopa in the Chicken (Gallus domesticus)," Brit. Poult. Sci., 29: 167-170 (1988).
G. Colmano et al., "Effect of Metyrapone and DDD on Infectious Diseases," Poult. Sci. 50: 850-854 (1971).
Walter B. Gross, "Effect of Adrenal Blocking Chemicals on Viral and Respiratory Infectious of Chickens," Can J. Vet. Res., 53: 48-51 (1988).
D. L. Thompson et al., "Cell-Mediated Immunity in Marek's Disease Virus-Infected Chickens Genetically Selected for High and Low Concentrations of Plasma Corticosterone," Am. J. Vet. Res. 41(1): 91-96 (Jan. 1980).
P. Thaxton et al., "Modification of High Temperature and ACTH Induced Immunodepression by Metyrapone," Poult. Sci. 52: 618-624 (1973).
Deck Randall E.
Fado John D.
Silverstein M. Howard
The United States of America as represented by the Secretary of
Waddell Frederick E.
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